A breakthrough using “reverse pharmacology” identified and characterized acyl ghrelin from
the stomach as the endogenous cognate ligand for the growth hormone (GH) secretagogue …

The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3
position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of …

OBJECTIVE—Obestatin is a newly discovered peptide encoded by the ghrelin gene whose
biological functions are poorly understood. We investigated obestatin effect on survival of β …

Background In recent years the interest on the relationship of gut hormones to bone
processes has increased and represents one of the most interesting aspects in skeletal …

GPR39 is a vertebrate G protein-coupled receptor related to the ghrelin/neurotensin receptor
subfamily. The receptor is expressed in a range of tissues including the pancreas …

The G-protein coupled receptor GPR39 is abundantly expressed in various tissues and can
be activated by changes in extracellular Zn2+ in physiological concentrations. Previously …

It has been postulated that multiple-marker methods may have added ability, over single-
marker methods, to detect genetic variants associated with disease. The Wellcome Trust …

Obestatin, a novel 23 amino acid amidated peptide encoded by the same gene with ghrelin,
was initially reported to reduce food intake, body weight gain, gastric emptying and suppress …

Obestatin is a 23-amino acid peptide hormone released from the stomach and is present not
only in the gastrointestinal tract, but also in the spleen, mammary gland, breast milk and …

There is growing evidence supporting a multifactorial etiology that includes genetic,
neurochemical, and physiological components for eating disorders above and beyond the …