The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

VS Peche, TA Pietka, M Jacome-Sosa… - Nature …, 2023 - nature.com
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

YJ Lee, KJ Shin, HJ Jang, JS Ryu, CY Lee, JH Yoon… - Developmental cell, 2023 - cell.com
Exosomes transport a variety of macromolecules and modulate intercellular communication
in physiology and disease. However, the regulation mechanisms that determine exosome …

Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer

JV Lee, F Housley, C Yau, R Nakagawa… - Nature …, 2022 - nature.com
Few patients with triple negative breast cancer (TNBC) benefit from immune checkpoint
inhibitors with complete and durable remissions being quite rare. Oncogenes can regulate …

Extracellular vesicle-mediated interorgan communication in metabolic diseases

S Hu, Y Hu, W Yan - Trends in Endocrinology & Metabolism, 2023 - cell.com
The body partially maintains metabolic homeostasis through interorgan communication
between metabolic organs under physiological conditions. This crosstalk is known to be …

Extracellular vesicles linking inflammation, cancer and thrombotic risks

S Beck, B Hochreiter, JA Schmid - Frontiers in cell and developmental …, 2022 - frontiersin.org
Extracellular vesicles (EVs) being defined as lipid-bilayer encircled particles are released by
almost all known mammalian cell types and represent a heterogenous set of cell fragments …

Exosome-derived noncoding RNAs: Function, mechanism, and application in tumor angiogenesis

K Yang, Q Zhou, B Qiao, B Shao, S Hu, G Wang… - … Therapy-Nucleic Acids, 2022 - cell.com
Exosomes are extracellular vesicles released by various cell types that perform various
biological functions, mainly mediating communication between different cells, especially …

DNA Nanowire Guided-Catalyzed Hairpin Assembly Nanoprobe for In Situ Profiling of Circulating Extracellular Vesicle-Associated MicroRNAs

Y Zhang, Y Wu, S Luo, C Yang, G Zhong, G Huang… - ACS …, 2022 - ACS Publications
Extracellular vesicle-associated miRNAs (EV-miRNAs) are emerging as a new type of
noninvasive biomarker for disease diagnosis. Their relatively low abundance, however …

[HTML][HTML] Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer

K Rubio, AJ Romero-Olmedo, P Sarvari… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a
patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an …