RAS proteins are small GTPases, which serve as master regulators of a myriad of signaling
cascades involved in highly diverse cellular processes. RAS oncogenes have been …

Fru-2, 6-P2 (fructose 2, 6-bisphosphate) is a signal molecule that controls glycolysis. Since
its discovery more than 20 years ago, inroads have been made towards the understanding …

ADP-ribosylation controls many processes, including transcription, DNA repair, and bacterial
toxicity. ADP-ribosyltransferases and poly-ADP-ribose polymerases (PARPs) catalyze mono …

Here, we present MultiProt, a fully automated highly efficient technique to detect multiple
structural alignments of protein structures. MultiProt finds the common geometrical cores …

Ras and its effector Raf are key mediators of the Ras/Raf/MEK/ERK signal transduction
pathway. Mutants of residue Q61 impair the GTPase activity of Ras and are found …

In recent years small G proteins have become an intensively studied group of regulatory
GTP hydrolases involved in cell signaling. More than 100 small G proteins have been …

The signalling functions of Rho‐family GTPases are based on the formation of distinctive
protein–protein complexes. Invaluable insights into the structure–function relationships of …

Transformation efficiencies of Ras mutants at residue 61 range over three orders of
magnitude, but the in vitro GTPase activity decreases 10-fold for all mutants. We show that …

The elucidation of the structure of the RasGAP complex provides what is perhaps the most
detailed link between protein structure and cancer causing mutations. In particular, it is …

The hydrolysis reaction of guanosine triphosphate (GTP) by p21ras (Ras) has been
modeled by using the ab initio type quantum mechanical–molecular mechanical …