Relevance of earth-bound extremophiles in the search for extraterrestrial life

L Carré, G Zaccai, X Delfosse, E Girard, B Franzetti - Astrobiology, 2022 - liebertpub.com
The recent discovery of extrasolar Earth-like planets that orbit in their habitable zone of their
system, and the latest clues of the presence of liquid water in the subsurface of Mars and in …

Lanthanide-based optical probes of biological systems

U Cho, JK Chen - Cell chemical biology, 2020 - cell.com
The unique photophysical properties of lanthanides, such as europium, terbium, and
ytterbium, make them versatile molecular probes of biological systems. In particular, their …

Structure Determination of Challenging Protein–Peptide Complexes Combining NMR Chemical Shift Data and Molecular Dynamics Simulations

A Mondal, GVT Swapna, MM Lopez… - Journal of chemical …, 2023 - ACS Publications
Intrinsically disordered regions of proteins often mediate important protein–protein
interactions. However, the folding-upon-binding nature of many polypeptide–protein …

Solution structure of recombinant Pvfp-5β reveals insights into mussel adhesion

MA Morando, F Venturella, M Sollazzo… - Communications …, 2022 - nature.com
Some marine organisms can resist to aqueous tidal environments and adhere tightly on wet
surface. This behavior has raised increasing attention for potential applications in medicine …

The nuclear magnetic resonance relaxation data analysis in solids: general R1/R1ρ equations and the model-free approach

R Kurbanov, T Zinkevich… - The Journal of chemical …, 2011 - pubs.aip.org
The advantage of the solid state NMR for studying molecular dynamics is the capability to
study slow motions without limitations: in the liquid state, if orienting media are not used, all …

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

C Olivieri, Y Wang, GC Li, M VS, J Kim, BR Stultz… - Elife, 2020 - elifesciences.org
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent
protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase …

Dynamics, a powerful component of current and future in silico approaches for protein design and engineering

B Surpeta, CE Sequeiros-Borja… - International Journal of …, 2020 - mdpi.com
Computational prediction has become an indispensable aid in the processes of engineering
and designing proteins for various biotechnological applications. With the tremendous …

[HTML][HTML] Characterization of backbone dynamics using solution NMR spectroscopy to discern the functional plasticity of structurally analogous proteins

AA Kawale, BM Burmann - STAR protocols, 2021 - Elsevier
The comprehensive delineation of inherent dynamic motions embedded in proteins, which
can be crucial for their functional repertoire, is often essential yet remains poorly understood …

[HTML][HTML] Slow motions in microcrystalline proteins as observed by MAS-dependent 15N rotating-frame NMR relaxation

A Krushelnitsky, T Zinkevich, B Reif… - Journal of Magnetic …, 2014 - Elsevier
Abstract 15 N NMR relaxation rate R 1ρ measurements reveal that a substantial fraction of
residues in the microcrystalline chicken alpha-spectrin SH3 domain protein undergoes …

Internal protein dynamics on ps to μs timescales as studied by multi-frequency 15N solid-state NMR relaxation

T Zinkevich, V Chevelkov, B Reif, K Saalwächter… - Journal of biomolecular …, 2013 - Springer
A comprehensive analysis of the dynamics of the SH3 domain of chicken alpha-spectrin is
presented, based upon 15 NT 1 and on-and off-resonance T 1ρ relaxation times obtained on …