Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular
processes in neurons, the dysregulation of which compromises normal brain function. The …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptor,
which play a central role in learning, memory, and synaptic development. NMDARs are …

S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein
function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group …

Summary N-methyl-D-aspartate (NMDA) receptors constitute a major subtype of glutamate
receptors at extrasynaptic sites that link multiple intracellular catabolic processes …

Nitric oxide (NO) is a multifunctional signalling molecule and a neurotransmitter that plays
an important role in physiological and pathophysiological processes. In physiological …

Three closely related forms of glycogen synthase kinase 3 (GSK-3α, GSK-3β and GSK-3β2)
have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division …

N-Methyl-d-aspartate (NMDA) receptors are critical for neuronal development and synaptic
plasticity. The molecular mechanisms underlying the synaptic localization and functional …