In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Highlights•Protein–protein interactions are essential for almost all cell processes.•Peptides
are ideal candidates for targeting protein–protein interactions (PPIs).•We survey screening …

Immune imbalance of T lymphocyte subsets is a hallmark of psoriasis, but the molecular
mechanisms underlying this aspect of psoriasis pathology are poorly understood. Here, we …

Molecular recognition reagents are key tools for understanding biological processes and are
used universally by scientists to study protein expression, localisation and interactions …

Animals respond to chronic hypoxia by increasing the levels of a transcription factor known
as the hypoxia‐inducible factor (HIF). HIF upregulates multiple genes, the products of which …

A novel Affimer-functionalised interdigitated electrode-based capacitive biosensor platform
was developed for detection and estimation of Her4, a protein tumour biomarker, in …

Antibodies have been indispensable tools in molecular biology, biochemistry and medical
research. However, a number of issues surrounding validation, specificity and batch …

Because protein-protein interactions underpin most biological processes, developing tools
that target them to understand their function or to inform the development of therapeutics is …

Abstract Glypican-3 (GPC3) is a promising new marker for hepatocellular carcinoma, but the
reported values for serum GPC3 differ markedly between currently available kits. Here we …

Hypoxia is a common characteristic of many types of solid tumors and is associated with
tumor propagation, malignant progression, and resistance to anti-cancer therapy. HIF-1 …