MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

PA Juge, JS Lee, E Ebstein, H Furukawa… - … England Journal of …, 2018 - Mass Medical Soc
Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD)(hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …

Interstitial lung disease throughout the rheumatoid arthritis disease course

GC McDermott, TJ Doyle, JA Sparks - Current opinion in …, 2021 - journals.lww.com
Subclinical and clinical ILD occur frequently in preclinical, early, and established RA and
may play a key role in RA-related autoantibody production and disease progression. Further …

Recent advances in rheumatoid arthritis-associated interstitial lung disease

PA Juge, B Crestani, P Dieudé - Current Opinion in Pulmonary …, 2020 - journals.lww.com
The phenotypical, environmental, and genetic similarities between IPF and RA-ILD have led
to a better understanding of the underlying pathogenesis of RA-ILD. Despite the …

Rheumatoid arthritis disease activity predicting incident clinically apparent rheumatoid arthritis–associated interstitial lung disease: a prospective cohort study

JA Sparks, X He, J Huang, EA Fletcher… - Arthritis & …, 2019 - Wiley Online Library
Objective To evaluate rheumatoid arthritis (RA) disease activity and risk of RA‐associated
interstitial lung disease (RA‐ILD). Methods We investigated disease activity and risk of RA …

Molecular programs of fibrotic change in aging human lung

S Lee, MN Islam, K Boostanpour, D Aran, G Jin… - Nature …, 2021 - nature.com
Lung fibrosis is increasingly detected with aging and has been associated with poor
outcomes in acute lung injury or infection. However, the molecular programs driving this pro …

A prospective study of lung disease in a cohort of early rheumatoid arthritis patients

A Robles-Pérez, P Luburich, S Bolivar, J Dorca… - Scientific reports, 2020 - nature.com
Lung disease is common in patients with rheumatoid arthritis (RA). The onset of lung
involvement in RA is not well known. The objective is to describe the features and evolution …

Risk factors for the progression of rheumatoid arthritis-related interstitial lung disease: clinical features, biomarkers, and treatment options

N Chen, CY Diao, J Gao, DB Zhao - Seminars in Arthritis and Rheumatism, 2022 - Elsevier
Objectives The clinical heterogeneity of the progression of rheumatoid arthritis-associated
interstitial lung disease (RA-ILD) is high, and there is a lack of consensus on the clinical …

Obstructive sleep apnea and subclinical interstitial lung disease in the Multi-Ethnic Study of Atherosclerosis (MESA)

JS Kim, AJ Podolanczuk, P Borker… - Annals of the …, 2017 - atsjournals.org
Rationale: Obstructive sleep apnea (OSA) has been postulated to contribute to idiopathic
pulmonary fibrosis by promoting alveolar epithelial injury via tractional forces and …

Upregulation of citrullination pathway: from autoimmune to idiopathic lung fibrosis

KD Samara, A Trachalaki, E Tsitoura… - Respiratory …, 2017 - Springer
Background Increased protein citrullination and peptidylarginine deiminases (PADIs), which
catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and …

Recent advances in the pathogenesis, prediction, and management of rheumatoid arthritis-associated interstitial lung disease

C Johnson - Current Opinion in Rheumatology, 2017 - journals.lww.com
The ability to identify risk factors for preclinical RA-ILD has been enhanced, but the proper
management strategy for these patients is yet to be defined. ACPAs and cigarette smoking …