Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Introduction: The carbonic anhydrases (CAs, EC 4.2. 1.1), a group of ubiquitously expressed
metalloenzymes, are involved in numerous physiological and pathological processes, as …

Carbonic anhydrases (CAs) are enzymes that catalyze the interconversion of CO 2 and HCO
3−. In nature, there are multiple families of CA, designated with the Greek letters α through θ …

Carbonic anhydrases (CAs, Enzyme Commission number 4.2. 1.1) catalyze a simple but
fundamental reaction, CO2 hydration to yield bicarbonate and protons. CAs belonging to the …

Introduction: All microorganisms that cause diseases or illnesses to their host are defined as
pathogens. In this paper we will review the current state of the art for inhibiting parasite …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread enzymes in all life kingdoms with
five distinct genetic families known to date, the α-, β-, γ-, δ-and ζ-CAs. With the exception of …

The β-carbonic anhydrases (β-CAs) are a diverse but structurally related group of zinc-
metalloenzymes found in eubacteria, plant chloroplasts, red and green algae, and in the …

Carbon dioxide (CO2), a vital molecule of the carbon cycle, is a critical component in living
organisms' metabolism, performing functions that lead to the building of compounds …

Leishmaniasis is an infection provoked by protozoans belonging to the genus Leishmania.
Among the many species and subsepecies of such protozoa, Leishmania donovani chagasi …

A series of N-mono-and N, N-disubstituted dithiocarbamates have been investigated as
inhibitors of three β-carbonic anhydrases (CAs, EC 4.2. 1.1) from the fungal pathogens …