Background: Platelet-rich plasma (PRP) is a blood-derived preparation whose use has
grown exponentially in orthopaedic practice. However, there remains an unclear …

Purpose of review Bone fracture healing is a complex physiological process relying on
numerous cell types and signals. Inflammatory factors secreted by immune cells help to …

The transforming growth factor beta (TGF‐β) family forms a group of three isoforms, TGF‐β1,
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …

Fracture non-union remains a clinical problem despite advances in the understanding of
basic science and technology. Each fracture has a unique personality as does the patient …

Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in
response to various physiologic triggers. Traditionally thought to be solely involved in the …

Platelets have a central function in repairing vascular damage and stopping acute blood
loss. They are equally central to thrombus formation in cardiovascular diseases such as …

Introduction. The management of bisphosphonate‐related osteonecrosis of the jaw
(BRONJ), with no evidence‐based guidelines, remains controversial. We aimed to evaluate …

Background Treatment of large bone defects and fracture healing complications (delayed
and non-union) presents a substantial challenge for orthopaedic surgeons. Given that bone …

High tibial osteotomy (HTO) is a widely accepted and performed procedure to treat medial
knee arthrosis. The aim of this review is to evaluate the different surgical options in medial …

A two-decade long research has expedited knowledge about tissue repair mechanisms, and
the field of Regenerative Medicine is gaining ground stimulated by novel insights and the …