[HTML][HTML] Insulin resistance: from mechanisms to therapeutic strategies

SH Lee, SY Park, CS Choi - Diabetes & metabolism journal, 2022 - synapse.koreamed.org
Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

[HTML][HTML] Metabolic-associated fatty liver disease and lipoprotein metabolism

J Heeren, L Scheja - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer

B Paul, M Lewinska, JB Andersen - JHEP reports, 2022 - Elsevier
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

DH Ipsen, J Lykkesfeldt, P Tveden-Nyborg - Cellular and molecular life …, 2018 - Springer
Non-alcoholic fatty liver disease (NAFLD) is currently the world's most common liver
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …

Recent insights into the pathogenesis of nonalcoholic fatty liver disease

JP Arab, M Arrese, M Trauner - Annual Review of Pathology …, 2018 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …

Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Q Ye, Y Liu, G Zhang, H Deng, X Wang, L Tuo… - Nature …, 2023 - nature.com
Metabolic associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic
disorders, including steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis. We …

Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease

S Softic, DE Cohen, CR Kahn - Digestive diseases and sciences, 2016 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome.
Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

RJ Perry, VT Samuel, KF Petersen, GI Shulman - Nature, 2014 - nature.com
Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …

Nonalcoholic fatty liver disease: pathogenesis and disease spectrum

T Hardy, F Oakley, QM Anstee… - Annual review of …, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …

Mechanisms for insulin resistance: common threads and missing links

VT Samuel, GI Shulman - Cell, 2012 - cell.com
Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …