Gut microbiota in pathophysiology, diagnosis, and therapeutics of inflammatory bowel disease

H Pandey, D Jain, DWT Tang, SH Wong… - Intestinal …, 2023 - pmc.ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a multifactorial disease, which is thought to be an
interplay between genetic, environment, microbiota, and immune-mediated factors …

Inflammation and gastrointestinal Candida colonization

CA Kumamoto - Current opinion in microbiology, 2011 - Elsevier
Candida organisms commonly colonize the human gastrointestinal tract as a component of
the resident microbiota. Their presence is generally benign. Recent studies, however, show …

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

N Kayagaki, IB Stowe, BL Lee, K O'Rourke… - Nature, 2015 - nature.com
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli,
Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse …

Cutting edge: IL-17–secreting innate lymphoid cells are essential for host defense against fungal infection

A Gladiator, N Wangler… - The Journal of …, 2013 - journals.aai.org
IL-17–mediated immunity has emerged as a crucial host defense mechanism against fungal
infections. Although Th cells are generally thought to act as the major source of IL-17 in …

Mouse model of oropharyngeal candidiasis

NV Solis, SG Filler - Nature protocols, 2012 - nature.com
Oropharyngeal candidiasis is a frequent cause of morbidity in patients with defects in cell-
mediated immunity or saliva production. Animal models of this infection are important for …

A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans

J Tomalka, S Ganesan, E Azodi, K Patel… - PLoS …, 2011 - journals.plos.org
Candida sp. are opportunistic fungal pathogens that colonize the skin and oral cavity and,
when overgrown under permissive conditions, cause inflammation and disease. Previously …

Antifungal Activity of Natural Compounds vs. Candida spp.: A Mixture of Cinnamaldehyde and Eugenol Shows Promising In Vitro Results

IM Saracino, C Foschi, M Pavoni, R Spigarelli… - Antibiotics, 2022 - mdpi.com
Candida spp. are commensal organisms of the skin, mucous membranes, gastrointestinal
tract, blood, and vagina of animals and humans. In recent decades, the incidence of human …

Role of neutrophils in IL-17–dependent immunity to mucosal candidiasis

AR Huppler, HR Conti… - The Journal of …, 2014 - journals.aai.org
Oropharyngeal candidiasis (OPC), caused by the commensal fungus Candida albicans, is
an opportunistic infection associated with infancy, AIDS, and IL-17–related primary …

The interleukin (IL) 17R/IL-22R signaling axis is dispensable for vulvovaginal candidiasis regardless of estrogen status

BM Peters, BM Coleman, HME Willems… - The Journal of …, 2020 - academic.oup.com
Candida albicans, a ubiquitous commensal fungus that colonizes human mucosal tissues
and skin, can become pathogenic, clinically manifesting most commonly as oropharyngeal …

Accelerated wound healing phenotype in Interleukin 12/23 deficient mice

MAT Matias, JM Saunus, S Ivanovski, LJ Walsh… - Journal of …, 2011 - Springer
Background The concept that a strong inflammatory response involving the full complement
of cytokines and other mediators is critical for unimpaired healing has been challenged by …