Despite encouraging progress over the past decade, malaria remains a major global health
challenge. Its severe form accounts for the majority of malaria-related deaths, and early …

Malaria continues to cause untold hardship to inhabitants of malaria-endemic regions,
causing significant morbidity and mortality that severely impact global health and the …

Host responses to infection with the malaria parasite Plasmodium falciparum vary among
individuals for reasons that are poorly understood. Here we reveal metabolic perturbations …

Malaria is one of the most severe infectious diseases affecting humans and it is caused by
protozoan pathogens of the species Plasmodium (spp.). The malaria parasite Plasmodium is …

Malaria transmission and endemicity in Africa remains hugely disproportionate compared to
the rest of the world. The complex life cycle of P. falciparum (Pf) between the vertebrate …

Pregnenolone sulfate is a steroid metabolite of the steroidogenesis precursor,
pregnenolone, with similar functional properties, including immunosuppression. We recently …

Background Individuals infected with SARS-CoV-2 vary greatly in their disease severity,
ranging from asymptomatic infection to severe disease. The regulation of gene expression is …

The appearance of increasing drug resistance in apicomplexan intracellular Plasmodium
falciparum presents a significant challenge. P. falciparum infection results in cerebral …

The regulation of immune cell responses to infection is a complex process that involves
various molecular mechanisms, including epigenetic regulation. DNA methylation has been …

Vector‐borne diseases that account for more than 700 000 deaths annually are carried by
arthropods that spread viruses, bacteria, and parasites. Effective vaccines are needed for …