Neurological consequences of obesity

PD O'Brien, LM Hinder, BC Callaghan… - The Lancet …, 2017 - thelancet.com
The high prevalence of obesity is associated with an enormous medical, social, and
economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by …

Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

MP Mattson - Cell metabolism, 2012 - cell.com
Evolution favored individuals with superior cognitive and physical abilities under conditions
of limited food sources, and brain function can therefore be optimized by intermittent dietary …

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and …

S Wang, S Ahmadi, R Nagpal, S Jain, SP Mishra… - Geroscience, 2020 - Springer
Increased inflammation associated with leaky gut is a major risk factor for morbidity and
mortality in older adults; however, successful preventive and therapeutic strategies against …

Obesity reduces cognitive and motor functions across the lifespan

C Wang, JSY Chan, L Ren, JH Yan - Neural plasticity, 2016 - Wiley Online Library
Due to a sedentary lifestyle, more and more people are becoming obese nowadays. In
addition to health‐related problems, obesity can also impair cognition and motor …

Obesity-induced cognitive impairment in older adults: a microvascular perspective

P Balasubramanian, T Kiss… - American Journal …, 2021 - journals.physiology.org
Over two-thirds of individuals aged 65 and older are obese or overweight in the United
States. Epidemiological data show an association between the degree of adiposity and …

Adipose tissue coregulates cognitive function

N Oliveras-Cañellas, A Castells-Nobau… - Science …, 2023 - science.org
Obesity is associated with cognitive decline. Recent observations in mice propose an
adipose tissue (AT)–brain axis. We identified 188 genes from RNA sequencing of AT in …

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders

G Morris, BK Puri, AJ Walker, M Maes… - Neuroscience & …, 2019 - Elsevier
Activated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and
consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric …

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity

N Castanon, G Luheshi, S Layé - Frontiers in neuroscience, 2015 - frontiersin.org
Obesity is associated with a high prevalence of mood disorders and cognitive dysfunctions
in addition to being a significant risk factor for important health complications such as …

Body mass index and decline of cognitive function

S Kim, Y Kim, SM Park - PLOS one, 2016 - journals.plos.org
Background The association between body mass index (BMI) and cognitive function is a
public health issue. This study investigated the relationship between obesity and cognitive …

Neuropsychiatric comorbidity in obesity: role of inflammatory processes

N Castanon, J Lasselin, L Capuron - Frontiers in endocrinology, 2014 - frontiersin.org
Neuropsychiatric symptoms are frequent in obesity. In addition to their substantial economic
and health impact, these symptoms significantly interfere with the quality of life and social …