[HTML][HTML] Treatment of liver fibrosis: Past, current, and future

CY Zhang, S Liu, M Yang - World Journal of Hepatology, 2023 - ncbi.nlm.nih.gov
Liver fibrosis accompanies the progression of chronic liver diseases independent of
etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated …

The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression

T Lan, W Wang, X Zeng, Y Tong, Z Mao… - … and Biophysical Research …, 2023 - Elsevier
Ferroptosis is a type of nonapoptotic necrotic cell death characterized by iron-dependent
lipid peroxidation. Saikosaponin A (SsA), a natural bioactive triterpenoid saponin extracted …

Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells

C Zeng, D Nie, X Wang, S Zhong, X Zeng, X Liu, K Qiu… - Molecular Cancer, 2024 - Springer
Background In the ongoing battle against BCR-ABL+ leukemia, despite significant advances
with tyrosine kinase inhibitors (TKIs), the persistent challenges of drug resistance and the …

[HTML][HTML] LACTB suppresses liver cancer progression through regulation of ferroptosis

K Zeng, N Huang, N Liu, X Deng, Y Mu, X Zhang… - Redox Biology, 2024 - Elsevier
Ferroptosis, driven by iron-dependent phospholipid peroxidation, is emerging as an intrinsic
cancer defense mechanism. However, the regulatory networks involved in ferroptosis …

Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression

W Deng, J Ai, W Zhang, Z Zhou, M Li, L Yan… - Journal of translational …, 2023 - Springer
Background The hepatitis B virus X (HBx) protein is an established cause of hepatitis B virus
(HBV)-induced hepatocellular carcinoma (HCC). Whether arginine methylation regulates …

Novel mechanistic insights–A brand new Era for anti-HBV drugs

W Lyu, H Qin, Q Li, D Lu, C Shi, K Zhao, S Zhang… - European Journal of …, 2024 - Elsevier
Abstract Hepatitis B Virus (HBV) remains a critical global health issue, with substantial
morbidity and mortality. Current therapies, including interferons and nucleoside analogs …

LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma

X Bai, J Li, X Guo, Y Huang, X Xu, A Tan, Y Jia… - Cell Death & …, 2024 - nature.com
In a retrospective analysis of clinical data from 587 DLBCL (diffuse large B-cell lymphoma)
patients in China, 13.8% of cases were associated with HBV (hepatitis B virus) infection …

Heat shock protein family A member 8 serving as a co-activator of transcriptional factor ETV4 up-regulates PHLDA2 to promote the growth of liver cancer

S Wang, Y Wang, G Yang, H Zhang, H Yuan… - Acta Pharmacologica …, 2023 - nature.com
Heat shock protein family A member 8 (HSPA8) participates in the folding or degradation of
misfolded proteins under stress and plays critical roles in cancer. In this study, we …

Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

PD Talukdar, U Chatterji - Signal Transduction and Targeted Therapy, 2023 - nature.com
Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …