For centuries, philosophers and scientists have been fascinated by the principles and
implications of regeneration in lower vertebrate species. Two features have made zebrafish …

Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

Cardiac injury in mammals and amphibians typically leads to scarring, with minimal
regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully …

Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Questions about how and why tissue regeneration occurs have captured the attention of
countless biologists, biomedical engineers and clinicians. Regenerative capacity differs …

While mammals have a limited capacity to repair bone defects, zebrafish can completely
regenerate amputated bony structures of their fins. Fin regeneration is dependent on …

Ablation studies are used to elucidate cell lineage relationships, developmental roles for
specific cells during embryogenesis and mechanisms of tissue regeneration. Previous …

Inventive genetic screens in zebrafish are revealing new genetic pathways that control
vertebrate development, disease and behaviour. By exploiting the versatility of zebrafish …