BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

Recurrent pregnancy loss is a complex health challenge with no universally accepted
definition. Inconsistency in definitions involves not only the number of spontaneous …

STUDY QUESTION What are the updates for the recommended management of women with
recurrent pregnancy loss (RPL) based on the best available evidence in the literature from …

• In this guideline, recurrent miscarriage has been defined as three or more first trimester
miscarriages. However, clinicians are encouraged to use their clinical discretion to …

Advanced age is a primary risk factor for female infertility due to reduced ovarian reserve
and declining oocyte quality. However, as an important contributing factor, the role of …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …

Male infertility is an increasing and serious medical concern, though the mechanism
remains poorly understood. Impaired male reproductive function affects approximately half …

Assessments of sperm DNA damage are controversial because of perceived uncertainties
over the relationship with pregnancy and the limited range of therapies available should …

Objectives Successful pregnancy involves the homeostasis between maternal decidua and
fetoplacental units, whose disruption contributes to compromised pregnancy outcomes …

Background Infertility, which is defined as the inability to conceive after at least 12 months of
regular unprotected sexual intercourses, affects about 15–20% of couples worldwide and a …