Ex vivo bone models and their potential in preclinical evaluation
Abstract Purpose of Review Novel therapies for damaged and diseased bone are being
developed in a preclinical testing process consisting of in vitro cell experiments followed by …
developed in a preclinical testing process consisting of in vitro cell experiments followed by …
Public RNA-seq data-based identification and functional analyses reveal that MXRA5 retains proliferative and migratory abilities of dental pulp stem cells
K Yoshida, S Suzuki, H Yuan, A Sato… - Scientific Reports, 2023 - nature.com
Dental pulp stem cells (DPSC) usually remain quiescent in the dental pulp tissue; however,
once the dental pulp tissue is injured, DPSCs potently proliferate and migrate into the injury …
once the dental pulp tissue is injured, DPSCs potently proliferate and migrate into the injury …
[HTML][HTML] Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats
Y Zeng, M Zhou, L Chen, H Fang, S Liu, C Zhou, J Sun… - Bioactive materials, 2020 - Elsevier
Graphene Oxide (GO)-related hydrogels have been extensively studied in hard tissue repair,
because GO can not only enhance the mechanical properties of polymers but also promote …
because GO can not only enhance the mechanical properties of polymers but also promote …
[HTML][HTML] Procyanidin B2 enhances anti-inflammatory responses of periodontal ligament cells by inhibiting the dominant negative pro-inflammatory isoforms of …
T Yamamoto, H Yuan, S Suzuki, E Nemoto… - Journal of Dental …, 2024 - Elsevier
Background/purpose Periodontal breakdown in periodontitis is exacerbated by pro-
inflammatory responses of periodontal stromal cells such as periodontal ligament fibroblasts …
inflammatory responses of periodontal stromal cells such as periodontal ligament fibroblasts …
The Role of DSPP in Dentine Formation and Hereditary Dentine Defects.
JIA Jie, B Zhuan, S Yaling - Chinese Journal of Dental …, 2024 - search.ebscohost.com
The dentine sialophosphoprotein (DSPP) gene is the only identified causative gene for
dentinogenesis imperfecta type 2 (DGI-II), dentinogenesis imperfecta type 3 (DGI-III) and …
dentinogenesis imperfecta type 2 (DGI-II), dentinogenesis imperfecta type 3 (DGI-III) and …
[HTML][HTML] The histone deacetylase inhibitor MS-275 enhances the matrix mineralization of dental pulp stem cells by inducing fibronectin expression
S Suzuki, K Sasaki, RR Fahreza, E Nemoto… - Journal of Dental …, 2024 - Elsevier
Background/purpose The acetylation of histone H3 proteins keeps local chromatin regions
open and accessible, thereby facilitating transcriptional events. We recently reported …
open and accessible, thereby facilitating transcriptional events. We recently reported …
[HTML][HTML] Dynamic changes in chromatin accessibility during the differentiation of dental pulp stem cells reveal that induction of odontogenic gene expression is linked …
K Sasaki, S Suzuki, RR Fahreza, E Nemoto… - Journal of Dental …, 2024 - Elsevier
Chromatin accessibility alteration is a key epigenomic regulatory mechanism of
transcription. 1 Histone modifications, such as acetylation, methylation, and phosphorylation …
transcription. 1 Histone modifications, such as acetylation, methylation, and phosphorylation …
Cementogenic genes in human periodontal ligament stem cells are downregulated in response to osteogenic stimulation while upregulated by vitamin C treatment
Regeneration of periodontal tissues, particularly cementum, is key to regaining periodontal
attachment and health. Human periodontal ligament stem cells (hPDLSCs) have been …
attachment and health. Human periodontal ligament stem cells (hPDLSCs) have been …
[HTML][HTML] Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities
X Wang, S Suzuki, H Yuan, S Hirata-Tsuchiya… - Journal of Dental …, 2025 - Elsevier
Background/purpose Peroxisome proliferator-activated receptor γ (PPARγ) is a major
transcription factor of energy metabolism-associated genes, and three PPARγ isoforms have …
transcription factor of energy metabolism-associated genes, and three PPARγ isoforms have …
Compromised alveolar bone cells in a patient with dentinogenesis imperfecta caused by DSPP mutation
T Porntaveetus, N Nowwarote, T Osathanon… - Clinical Oral …, 2019 - Springer
Objectives Dentin sialophosphoprotein (DSPP) plays an important role in the mineralization
of both dentin and bones. The Dspp null mice developed periodontal diseases. Patients with …
of both dentin and bones. The Dspp null mice developed periodontal diseases. Patients with …