In Vitro Models for Investigating Intestinal Host–Pathogen Interactions

R McCoy, S Oldroyd, W Yang, K Wang… - Advanced …, 2024 - Wiley Online Library
Infectious diseases are increasingly recognized as a major threat worldwide due to the rise
of antimicrobial resistance and the emergence of novel pathogens. In vitro models that can …

Equine rotavirus A under the one health lens: potential impacts on public health

M Carossino, MA Vissani, ME Barrandeguy… - Viruses, 2024 - mdpi.com
Group A rotaviruses are a well-known cause of viral gastroenteritis in infants and children,
as well as in many mammalian species and birds, affecting them at a young age. This group …

[HTML][HTML] MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses

CE Heuberger, A Janney, N Ilott, A Bertocchi, S Pott… - Mucosal …, 2024 - Elsevier
Although intestinal epithelial cells (IECs) can express major histocompatibility complex class
II (MHC II), especially during intestinal inflammation, it remains unclear if antigen …

Sodium butyrate protects against rotavirus-induced intestinal epithelial barrier damage by activating AMPK-Nrf2 signaling pathway in IPEC-J2 cells

X Dong, Y Wang, X Zhu, L Shen, L Chen, L Niu… - International Journal of …, 2023 - Elsevier
Rotavirus (RV) mainly infects intestinal epithelial cells, which leads to diarrhea in newborn
piglets with dysfunction in the intestinal mucosal mechanical barrier. Sodium butyrate (SB) is …

Infection of porcine enteroids and 2D differentiated intestinal epithelial cells with rotavirus A to study cell tropism and polarized immune response

M Yan, A Su, S Pavasutthipaisit… - Emerging microbes & …, 2023 - Taylor & Francis
Intestinal epithelial cell interactions with enteric pathogens have been incompletely
elucidated owing to the lack of model systems that recapitulate the cellular diversity …

Using species a rotavirus reverse genetics to engineer chimeric viruses expressing SARS-CoV-2 spike epitopes

O Diebold, V Gonzalez, L Venditti, C Sharp… - Journal of …, 2022 - Am Soc Microbiol
Species A rotavirus (RVA) vaccines based on live attenuated viruses are used worldwide in
humans. The recent establishment of a reverse genetics system for rotoviruses (RVs) has …

Lipidomics reveals the significance and mechanism of the cellular ceramide metabolism for rotavirus replication

R Tao, X Cheng, L Gu, J Zhou, X Zhu, X Zhang… - Journal of …, 2024 - Am Soc Microbiol
As one of the most important causative agents of severe gastroenteritis in children, piglets,
and other young animals, species A rotaviruses have adversely impacted both human …

Cheminformatics bioprospection of selected medicinal plants metabolites against trypsin cleaved VP4 (spike protein) of rotavirus A

AA Lanrewaju, AM Enitan-Folami… - Journal of …, 2023 - Taylor & Francis
Rotaviruses have continued to be the primary cause of acute dehydrating diarrhoea in
children under five years of age despite the global introduction of four World Health …

[HTML][HTML] Evaluation of in vitro antirotaviral activity of lactoferrin from different species using a human intestinal model

D Graikini, C Conesa, I Abad, MD Pérez… - International Dairy …, 2024 - Elsevier
Rotaviruses are the leading agents of severe diarrheal disease in infants and young
children and complementary strategies to vaccination are needed. Therefore, we evaluated …

Human rotavirus replicates in salivary glands and primes immune responses in facial and intestinal lymphoid tissues of gnotobiotic pigs

C Nyblade, P Zhou, M Frazier, A Frazier, C Hensley… - Viruses, 2023 - mdpi.com
Human rotavirus (HRV) is a leading cause of viral gastroenteritis in children across the
globe. The virus has long been established as a pathogen of the gastrointestinal tract …