Iridium-catalyzed C–H activation and borylation has become as a powerful synthetic tool in
the past few decades because of the widespread applicability and versatility of organoboron …

Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

Nitriles are widely used vibrational probes; however, the interpretation of their IR
frequencies is complicated by hydrogen bonding (H-bonding) in protic environments. We …

The implementation of HCN-free transfer hydrocyanation reactions on laboratory scales has
recently been achieved by using HCN donor reagents under nickel-and Lewis acid co …

Nitrile derivatives play an important role in the synthesis of drugs and medicinal compounds;
and use to treat diseases such as major depression, generalized anxiety, HIV and mild …

The dual incorporation of two important functional groups—trifluoromethyl and cyano
moieties into one heterocyclic core in a single-step reaction represents an appealing but …

Molecular dynamics (MD) simulations are frequently carried out for proteins to investigate
the role of electrostatics in their biological function. The choice of force field (FF) can …

Nitriles have broad applications in medicinal chemistry, with more than 60 small molecule
drugs on the market containing the cyano functional group. In addition to the well-known …

Methods for C− H cyanation of pyridines are rare. Here, we report a method for C3‐selective
cyanation of pyridines by a tandem process with the reaction of an in situ generated …

As a non-invasive imaging technology, positron emission tomography (PET) plays a crucial
role in personalized medicine, including early diagnosis, patient screening, and treatment …