The postprandial actions of GLP-1 receptor agonists: the missing link for cardiovascular and kidney protection in type 2 diabetes

MC Thomas, MT Coughlan, ME Cooper - Cell Metabolism, 2023 - cell.com
Recent clinical trials in people with type 2 diabetes have demonstrated beneficial actions on
heart and kidney outcomes following treatment with GLP-1RAs. In part, these actions are …

Osteoporosis, genetics and hormones

R Rizzoli, JP Bonjour, SL Ferrari - Journal of molecular …, 2001 - jme.bioscientifica.com
Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics

TS Salameh, EM Rhea, K Talbot, WA Banks - Biochemical pharmacology, 2020 - Elsevier
Among the more promising treatments proposed for Alzheimer's disease (AD) and
Parkinson's disease (PD) are those reducing brain insulin resistance. The antidiabetics in …

Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson's disease

W Liu, J Jalewa, M Sharma, G Li, L Li, C Hölscher - Neuroscience, 2015 - Elsevier
Abstract Glucagon-like peptide 1 (GLP-1) is a growth factor. GLP-1 mimetics are on the
market as treatments for type 2 diabetes and are well tolerated. These drugs have shown …

The neuroprotection of liraglutide against ischaemia-induced apoptosis through the activation of the PI3K/AKT and MAPK pathways

H Zhu, Y Zhang, Z Shi, D Lu, T Li, Y Ding, Y Ruan… - Scientific reports, 2016 - nature.com
Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone that increases glucose-
dependent insulin secretion to reduce the glucose level. Liraglutide, a long-acting GLP-1 …

The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of …

HH Hansen, K Fabricius, P Barkholt… - Journal of …, 2015 - content.iospress.com
Recent studies indicate that glucagon-like peptide 1 (GLP-1) receptor agonists, currently
used in the management of type 2 diabetes, exhibit neurotrophic and neuroprotective effects …

Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms

B Vergès, V Aboyans, D Angoulvant… - Cardiovascular …, 2022 - Springer
Several randomized controlled trials have demonstrated the benefits of glucagon-like
peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with diabetes. In this …

Glucagon-like peptide-1 and the central/peripheral nervous system: crosstalk in diabetes

G Muscogiuri, RA DeFronzo, A Gastaldelli… - Trends in Endocrinology …, 2017 - cell.com
Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles
in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation …

NLRP3 inflammasome activation after ischemic stroke

PP Han, Y Han, XY Shen, ZK Gao, X Bi - Behavioural brain research, 2023 - Elsevier
Cerebral ischemia is a pathological condition resulting from the cessation or reduction of
blood supply to the cerebral arteries. Neurological deficits that are clinically relevant can …

Neuroprotective mechanisms of glucagon-like peptide-1-based therapies in ischemic stroke: an update based on preclinical research

X Yang, Q Qiang, N Li, P Feng, W Wei… - Frontiers in …, 2022 - frontiersin.org
The public and social health burdens of ischemic stroke have been increasing worldwide.
Hyperglycemia leads to a greater risk of stroke. This increased risk is commonly seen …