Statistical design of experiments (DoE) is a powerful tool for optimizing processes, and it has
been used in many stages of API development. This review summarizes selected …

Both enantiomers of 2, 3-bis (tert-butylmethylphosphino) quinoxaline (QuinoxP*), 1, 2-bis
(tert-butylmethylphosphino) benzene (BenzP*), and 1, 2-bis (tert-butylmethylphosphino)-4, 5 …

A series of seleno-containing polyfunctionalized compounds was synthesized exploring
cyanohydrin chemistry, including α-hydroxy esters, α-hydroxy acids, 1, 2-diols, and 1, 2 …

A ruthenocenyl phosphino‐oxazoline‐ruthenium complex (RuPHOX− Ru) catalyzed
asymmetric hydrogenation of α‐aryl keto acids has been successfully developed, affording …

The importance of Quality by Design (QbD) is being realized gradually, as it is gaining
popularity among the generic companies. However, the major hurdle faced by these …

The α-form of the first-line antituberculosis drug pyrazinamide (PZA), which is the
thermodynamically stable polymorph at ambient conditions, exhibits a fine needle shape …

A design of experiments (DoE) approach was applied to the development and optimization
of the manufacturing process to prepare linagliptin. DoE techniques such as a central …

GlaxoSmithKline (GSK) has identified casopitant as a potent NK1 antagonist. It was selected
for its potential activities on a number of therapeutic targets such as inflammatory bowel …

The DMAIC (Define, Measure, Analyse, Improve and Control) framework and associated
statistical tools have been applied to both identify and reduce variability observed in a …

Abstract Development of the arzoxifene hydrochloride drug substance manufacturing
process, first via a traditional approach and subsequently via an enhanced approach …