Our understanding of human natural killer (NK) cell development lags far behind that of
human B‐or T‐cell development. Much of our recent knowledge of this incomplete picture …

The thymus is the main producer of αβ T cells and is, therefore, crucial for a normal immune
system. The intrathymic developmental pathway of human αβ T cells has now been …

Profound cellular immunodeficiency occurs as the result of mutations in proteins involved in
both the differentiation and function of mature lymphoid cells. We describe here a novel …

Naïve T cells develop in the thymus and coordinate immune responses to new antigens;
however, mechanisms for their long-term persistence over the human life span remain …

Regulatory T cells (TREGs) constitutively expressing CD4, CD25, and the transcription factor
Foxp3 can prevent a wide range of experimental and spontaneous autoimmune diseases in …

Studies of human T cell development require robust model systems that recapitulate the full
span of thymopoiesis, from hematopoietic stem and progenitor cells (HSPCs) through to …

CD69, also known as activation inducer molecule, very early activation antigen, MLR-3 and
Leu-23, is a member of the natural killer (NK) cell gene complex family of signal transducing …

Human embryonic stem cells (hESC) are pluripotent stem cells. A major challenge in the
field of hESC is the establishment of specific differentiation protocols that drives hESC down …

Summary CD4+ CD25+ regulatory T cells prevent organ‐specific autoimmune diseases in
various animal models. We analysed human lymphoid tissues to identify similar CD25+ …

Thymomas are the only tumors that are proven to generate mature T cells from immature
precursors. It is unknown, however, whether intratumorous thymopoiesis has an impact on …