The ubiquitination pathway and proteasomal degradation machinery dominantly regulate
p53 tumor suppressor protein stability, localization, and functions in both normal and …

The tumor suppressor p53 and its homologues, p63 and p73, play a pivotal role in the
regulation of the DNA damage response, cellular homeostasis, development, aging, and …

Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD)
in children, causing severe clinical outcomes and even death. Here, we report an important …

Dopamine (DA) is a catecholamine that is an essential neurotransmitter in the human body.
Slight variation in its concentration and metabolism leads to severe neurological damage or …

The control of cell division is a cardinal issue in the field of cancer therapy. Indeed, beta-
tubulin is an essential protein in cell division process. Therefore it is the prime target of many …

Cardiomyocytes are under constant mechanical and metabolic stress, which makes
functional protein quality control (PQC) systems particularly important. Molecular …