[HTML][HTML] Anticancer activities of tetra-, penta-, and hexacyclic phenothiazines modified with quinoline moiety.

M Jeleń, B Morak-Młodawska, R Korlacki - Journal of Molecular Structure, 2023 - Elsevier
The quinoline molecule is a chemical motif showing a highly promising pharmacological
potential. Its numerous derivatives introduced into medicine revolutionized in the treatment …

Quinoline-based anti-oncogenic molecules: synthesis and biological evaluation

S Sharma, S Singh, D Yadav - Medicinal Chemistry, 2023 - benthamdirect.com
Quinoline and its analogues are found in various natural products, many of which are active
pharmacophores with significant bioactivities. This article discussed the plethora of …

Molecular docking simulation and anticancer assessment on human breast carcinoma cell line using novel bis (1, 4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile) and …

SK Salama, MF Mohamed, AF Darweesh… - Bioorganic …, 2017 - Elsevier
An efficient route for the synthesis of novel bis (1, 4-dihydropyrano [2, 3-c] pyrazole-5-
carbonitrile) derivatives is reported. The synthetic pathway involves one pot, synthesis of bis …

Molecular Docking Study for Binding Affinity of 2H‐thiopyrano[2,3‐b]quinoline Derivatives against CB1a

S Sharma, S Singh - Interdisciplinary Perspectives on …, 2023 - Wiley Online Library
Quinoline‐based molecules are major constituents in natural products, active
pharmacophores, and have excellent biological activities. Using 2H‐thiopyrano [2, 3‐b] …

Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents

RK Arafa, GH Hegazy, GA Piazza, AH Abadi - European journal of …, 2013 - Elsevier
Several derivatives with a quinoline scaffold and a flexible, semi-flexible or rigid side chains
at position 8 of the quinoline ring were synthesized and assessed for their in vitro activity …

Investigations of structural, spectral and electronic properties of enrofloxacin and boron complexes via quantum chemical calculation and molecular docking

K Sayin, A Üngördü - Spectrochimica Acta Part A: Molecular and …, 2019 - Elsevier
Quantum chemical analyses were performed over enrofloxacin and boron complexes. The
most stable isomer of enrofloxacin was examined at M062X/6-31+ G (d) level in gas phase …

Investigation of anticancer properties of caffeinated complexes via computational chemistry methods

K Sayin, A Üngördü - Spectrochimica Acta Part A: Molecular and …, 2018 - Elsevier
Computational investigations were performed for 1, 3, 7-trimethylpurine-2, 6-dione, 3, 7-
dimethylpurine-2, 6-dione, their Ru (II) and Os (III) complexes. B3LYP/6-311++ G (d …

An Organocatalytic Cascade Approach toward Polysubstituted Quinolines and Chiral 1, 4‐Dihydroquinolines–Unanticipated Effect of N‐Protecting Groups

X Zhang, X Song, H Li, S Zhang, X Chen… - Angewandte Chemie …, 2012 - Wiley Online Library
Organocatalytic cascade reactions have been established as a viable and efficient approach
to complex molecular architectures,[1] however, examples of the combination of powerful …

Quantum chemical calculations on sparfloxacin and boron complexes

A Üngördü, K Sayin - Chemical physics letters, 2019 - Elsevier
Density functional theory calculations were performed with M06-2X/6-31+ G (d) to examine
the structural and spectral features of sparfloxacin and its boron complexes and to reveal …

Microwave-assisted multicomponent synthesis of antiproliferative 2, 4-dimethoxy-tetrahydropyrimido [4, 5-b] quinolin-6 (7 H)-ones

SG Patel, A González-Bakker, RM Vala, PJ Patel… - RSC …, 2022 - pubs.rsc.org
In this study, we demonstrate a simple, highly efficient, rapid and convenient series of 2, 4-
dimethoxy-tetrahydropyrimido [4, 5-b] quinolin-6 (7H)-ones 4a–v. Microwave irradiation …