Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Genomics and pathotypes of the many faces of Escherichia coli

J Geurtsen, M de Been, E Weerdenburg… - FEMS microbiology …, 2022 - academic.oup.com
Escherichia coli is the most researched microbial organism in the world. Its varied impact on
human health, consisting of commensalism, gastrointestinal disease, or extraintestinal …

Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women

CJ Worby, HL Schreiber IV, TJ Straub, LR van Dijk… - Nature …, 2022 - nature.com
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of
infection being a significant risk factor. While the gut is a known reservoir for uropathogenic …

Engineering bacteria for diagnostic and therapeutic applications

DT Riglar, PA Silver - Nature Reviews Microbiology, 2018 - nature.com
Our ability to generate bacterial strains with unique and increasingly complex functions has
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …

Relationships between food and diseases: What to know to ensure food safety

M Gallo, L Ferrara, A Calogero, D Montesano… - Food Research …, 2020 - Elsevier
In recent years, the concept of food has undergone a radical transformation to the point of
attributing to foods, in addition to their nutritional and sensorial properties, an important role …

Advances in understanding the human urinary microbiome and its potential role in urinary tract infection

ML Neugent, NV Hulyalkar, VH Nguyen, PE Zimmern… - MBio, 2020 - Am Soc Microbiol
Recent advances in the analysis of microbial communities colonizing the human body have
identified a resident microbial community in the human urinary tract (UT). Compared to many …

The role of gut, vaginal, and urinary microbiome in urinary tract infections: from bench to bedside

T Meštrović, M Matijašić, M Perić, H Čipčić Paljetak… - Diagnostics, 2020 - mdpi.com
The current paradigm of urinary tract infection (UTI) pathogenesis takes into account the
contamination of the periurethral space by specific uropathogens residing in the gut, which …

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

CN Spaulding, RD Klein, S Ruer, AL Kau, HL Schreiber… - Nature, 2017 - nature.com
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) affect 150
million people annually,. Despite effective antibiotic therapy, 30–50% of patients experience …

Crosstalk between in situ root exudates and rhizobacteria to promote rice growth by selenium nanomaterials

L Jiao, X Cao, C Wang, F Chen, H Zou, L Yue… - Science of The Total …, 2023 - Elsevier
Maximizing the potential of plant–microbe systems offers great opportunities to confront
sustainability issues in agroecosystems. However, the dialog between root exudates and …

[HTML][HTML] The urinary microbiome and biological therapeutics: Novel therapies for urinary tract infections

C Kenneally, CP Murphy, RD Sleator… - Microbiological …, 2022 - Elsevier
The discovery of microbial communities in the urinary tract (the urobiome) has fundamentally
altered the previous doctrine regarding urine sterility and associated urinary disorders …