Type 1 and type 2 diabetes mellitus is a serious and lifelong condition commonly
characterised by abnormally elevated blood glucose levels due to a failure in insulin …

The history of stem cell therapies is one of a limited number of clinical applications despite a
vast therapeutic potential. Major breakthroughs in stem cell research have not yet enjoyed …

Hydrogel microcapsules have been extensively investigated for encapsulation of living cells
or cell aggregates for tissue engineering and regenerative medicine. 1, 2, 3 In general …

Harvesting, expansion, and directed differentiation of human bone marrow-derived
mesenchymal stem cells (BM-MSCs) could provide an autologous source of surrogate β …

The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate
worldwide. The status of diabetes has changed over the last three generations; whereas …

Background The two major obstacles in the successful transplantation of islets for diabetes
treatment are inadequate supply of insulin-producing tissue and immune rejection. Induction …

Diabetes is one of the most prevalent, costly, and debilitating diseases in the world.
Pancreas and islet transplants have shown success in re-establishing glucose control and …

Autoimmune diseases (ADs) are among the most significant health complications, with their
incidence rising in recent years. Type 1 diabetes (T1D), an AD, targets the insulin-producing …

Type 1 diabetes mellitus (T1DM) has been defined as an autoimmune disease
characterised by immune-mediated destruction of the pancreatic β cells, leading to absolute …

Due to shortage of donor tissue a cure for type 1 diabetes by pancreas organ or islet
transplantation is an option only for very few patients. Gene therapy is an alternative …