A closer look at amyloid ligands, and what they tell us about protein aggregates

TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …

Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores

P Verwilst, HS Kim, S Kim, C Kang… - Chemical Society Reviews, 2018 - pubs.rsc.org
Historically, in Alzheimer's disease research, a lot of attention has been paid to the
development of highly selective fluorophores for beta amyloid plaques. With a shift in the …

Flotation separation of molybdenite from chalcopyrite using rhodanine-3-acetic acid as a novel and effective depressant

C Wang, R Liu, M Wu, Z Xu, M Tian, Z Yin, W Sun… - Minerals …, 2021 - Elsevier
The selective separation of molybdenite from chalcopyrite is difficult because of their similar
floatability in the presence of a collector. In this study, rhodanine-3-acetic acid (3-Rd) was …

[图书][B] Small animal imaging: basics and practical guide

F Kiessling, BJ Pichler - 2010 - books.google.com
Small animal imaging has been recognized as an important tool in preclinical research.
Nevertheless, the results of non-invasive imaging are often disappointing owing to choice of …

Molecular tools to detect alloforms of Aβ and Tau: Implications for multiplexing and multimodal diagnosis of Alzheimer's disease

H Arora, M Ramesh, K Rajasekhar… - Bulletin of the …, 2020 - academic.oup.com
The advancements in the field of imaging and diagnostics have been benefitted by the
concurrent expansion of molecular probes space to monitor the diverse biological targets …

Heparan sulfate as a therapeutic target in tauopathies: insights from zebrafish

SM Alavi Naini, N Soussi-Yanicostas - Frontiers in cell and …, 2018 - frontiersin.org
Microtubule-associated protein tau (MAPT) hyperphosphorylation and aggregation, are two
hallmarks of a family of neurodegenerative disorders collectively referred to as tauopathies …

Synthesis and biological activity of rhodanine-furan conjugates: A review

Y Matiichuk, I Drapak, N Darmograi… - Current Chemistry …, 2024 - growingscience.com
Rhodanines are recognized as privileged heterocycles in medicinal chemistry. The main
achievements include the development of drug-like molecules with numerous biological …

[PDF][PDF] 5-Phenyl-2-furaldehyde: synthesis, reactions and biological activities

AS Hassan, SA Osman, TS Hafez - Egypt. J. Chem, 2015 - ejchem.journals.ekb.eg
-PHENYL-2-furaldehyde is a good starting material for designing of.......
polyfunctionalized....... heterocyclic compounds with pharmacological interest such as …

Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity

S Ali Muhammad, S Ravi, A Thangamani - Medicinal Chemistry Research, 2016 - Springer
Novel N-substituted rhodanines 2a–g were synthesized by conventional and microwave-
assisted methods and tested for their anticancer activity. Structure–activity relationship of the …

Multichromatic fluorescence towards aberrant proteinaceous aggregates utilizing benzimidazole-based ICT fluorophores

J An, P Jangili, S Lim, YK Kim, P Verwilst… - Journal of Inclusion …, 2021 - Springer
The pathological origin of Alzheimer's disease (AD) remains uncharted terrain, despite
intensive investigation. Discriminating aberrant proteinaceous deposits, such as β-amyloid …