Targeting SARS-CoV-2 main protease for treatment of COVID-19: covalent inhibitors structure–activity relationship insights and evolution perspectives

G La Monica, A Bono, A Lauria… - Journal of medicinal …, 2022 - ACS Publications
The viral main protease is one of the most attractive targets among all key enzymes involved
in the SARS-CoV-2 life cycle. Covalent inhibition of the cysteine145 of SARS-CoV-2 MPRO …

Heparan sulfate proteoglycans in viral infection and treatment: a special focus on SARS-CoV-2

V De Pasquale, MS Quiccione, S Tafuri… - International Journal of …, 2021 - mdpi.com
Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …

Oral mucosa, saliva, and COVID-19 infection in oral health care

DS Atukorallaya, RK Ratnayake - Frontiers in medicine, 2021 - frontiersin.org
The SARS-CoV-2 virus has shaken the globe with an ongoing pandemic of COVID-19 and
has set challenges to every corner of the modern health care setting. The oral mucosa and …

SARS-CoV-2 cellular entry is independent of the ACE2 cytoplasmic domain signaling

T Karthika, J Joseph, VRA Das, N Nair, P Charulekha… - Cells, 2021 - mdpi.com
Recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV)-1 and-2
initiate virus infection by binding of their spike glycoprotein with the cell-surface receptor …

A fractional-order model of COVID-19 considering the fear effect of the media and social networks on the community

F Bozkurt, A Yousef, T Abdeljawad, A Kalinli… - Chaos, Solitons & …, 2021 - Elsevier
Since December 2019, the world has experienced from a virus, known as Covid-19, that is
highly transmittable and is now spread worldwide. Many mathematical models and studies …

SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways

SJ Oh, OS Shin - Journal of Microbiology, 2022 - Springer
With global expansion of the COVID-19 pandemic and the emergence of new variants,
extensive efforts have been made to develop highly effective antiviral drugs and vaccines …

A comprehensive review of natural flavonoids with anti-SARS-CoV-2 activity

JY Yang, YX Ma, Y Liu, XJ Peng, XZ Chen - Molecules, 2023 - mdpi.com
The COVID-19 pandemic caused by SARS-CoV-2 has majorly impacted public health and
economies worldwide. Although several effective vaccines and drugs are now used to …

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

BD López-Ayllón, A de Lucas-Rius… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins
encoded in its genome. Their roles during infection are still not completely understood. In …

Promising natural products against SARS‐CoV‐2: Structure, function, and clinical trials

Y Zhao, S Deng, Y Bai, J Guo, G Kai… - Phytotherapy …, 2022 - Wiley Online Library
The corona virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome
coronavirus type 2 (SARS‐COV‐2) poses a severe threat to human health and still spreads …

Molecular level dissection of critical spike mutations in SARS‐CoV‐2 variants of concern (VOCs): a simplified review

N Joshi, A Tyagi, S Nigam - ChemistrySelect, 2021 - Wiley Online Library
SARS‐CoV‐2 virus during its spread in the last one and half year has picked up critical
changes in its genetic code ie mutations, which have leads to deleterious epidemiological …