The first studies suggesting that abnormal expression of galectins is associated with cancer
were published more than 30 years ago. Today, the role of galectins in cancer is relatively …

Galectins are galactoside-binding proteins, exerting numerous functions inside and outside
the cell, particularly conferring adaptation to stress factors. For most of them, aberrant …

Analysis of large biomolecules including proteins has proven challenging using ambient
ionization mass spectrometry imaging techniques. Here, we have successfully optimized …

There is an exponentially growing interest in targeting immune checkpoint molecules in
breast cancer (BC), particularly in the triple-negative subtype where unmet treatment needs …

Tumor cells corrupt surrounding normal cells instructing them to support proliferative, pro-
angiogenic and immunosuppressive networks that favor tumorigenesis and metastasis. This …

Although considerable attention has been paid to the role of extracellular galectins in
modulating, positively or negatively, tumor growth and metastasis, we have witnessed a …

Background and Objective: Galectin-9 (Gal-9) is one of the galectin family members which
are known as proteins with β-galactoside-binding affinity. Accumulative evidence suggest …

Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-
galactosides. It has been described to be involved in apoptosis, proliferation and …

Aberrations in glycan and lectin expression and function represent one of the earliest
hallmarks of cancer. Among galectins, a conserved family of β-galactoside-binding lectins …

Breast cancer is an individually unique, multi-faceted and chameleonic disease, an eternal
challenge for the new era of high-integrated precision diagnostic and personalized …