The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and
proliferation. mTOR signaling is frequently dysregulated in oncogenic cells, and thus an …

Inflammatory bowel disease (IBD) is a debilitating and widespread immune-mediated illness
characterized by excessive inflammatory and effector mucosal responses leading to tissue …

Abstract Reactome (http://www. reactome. org) is a collaboration among groups at the
Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University …

Network analysis has an increasing role in our effort to understand the complexity of
biological systems. This is because of our ability to generate large data sets, where the …

Abstract SABIO-RK (http://sabio. h-its. org/) is a web-accessible database storing
comprehensive information about biochemical reactions and their kinetic properties. SABIO …

Superoxide production from antimycin-inhibited complex III in isolated mitochondria first
increased to a maximum then decreased as substrate supply was modulated in three …

Abstract SABIO-RK (http://sabiork. h-its. org/) is a manually curated database containing data
about biochemical reactions and their reaction kinetics. The data are primarily extracted from …

Infectious diseases can be difficult to cure, especially if the pathogen forms a biofilm. After
decades of extensive research into the morphology, physiology and genomics of biofilm …

Parkinson's disease (PD) arises as neurodegenerative disorder and characterized by
progressive deterioration of motor functions due to forfeiture of dopamine-releasing neurons …

The assessment of genome function requires a mapping between genome-derived entities
and biochemical reactions, and the biomedical literature represents a rich source of …