Primary cilia are microtubule‐based organelles that project from the cell surface to enable
transduction of various developmental signaling pathways. The process of intraflagellar …

Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …

Diarthrodial joint diseases, affecting hundreds of millions of people worldwide, mainly
include osteoarthritis and cartilage injuries. No consensus on joint disease models has been …

A conventional therapy for the treatment of osteoarthrosis is intra-articular injection of
hyaluronic acid, which requires repeated, frequent injections. To extend the …

Chondrocytes are the major cell type present in hyaline cartilage and they play a crucial role
in maintaining the mechanical resilience of the tissue through a balance of the synthesis and …

Cationic nanocarriers offer a promising solution to challenges in delivering drugs to
negatively charged connective tissues, such as to articular cartilage for the treatment of …

The aim of this study was to determine whether subchondral bone influences in situ
chondrocyte survival. Bovine explants were cultured in serum-free media over seven days …

PURPOSE: This systematic review provides (1) a synthesis of existing clinical evidence that
helps identify factors associated with the development of glenohumeral chondrolysis after …

Objectives Staphylococcus aureus (S. aureus) is the most commonly implicated organism in
septic arthritis, a condition that may be highly destructive to articular cartilage. Previous …

Background: Positively charged drug carriers are rapidly emerging as a viable solution for
long-standing challenges in delivery to dense, avascular, negatively charged tissues. These …