The pivotal role of NF-kB in the pathogenesis and therapeutics of Alzheimer's disease

E Sun, A Motolani, L Campos, T Lu - International journal of molecular …, 2022 - mdpi.com
Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide, with a
high prevalence that is expected to double every 20 years. Besides the formation of Aβ …

[HTML][HTML] Anti-amyloid immunotherapies for Alzheimer's disease: a 2023 clinical update

G Yadollahikhales, JC Rojas - Neurotherapeutics, 2023 - Elsevier
The amyloid cascade hypothesis is a useful framework for therapeutic development in
Alzheimer's disease (AD). Amyloid b 1-42 (Aβ) has been the main target of experimental …

Understanding neuropsychiatric symptoms in Alzheimer's disease: challenges and advances in diagnosis and treatment

A Pless, D Ware, S Saggu, H Rehman… - Frontiers in …, 2023 - frontiersin.org
Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) affect up to 97% of AD
patients, with an estimated 80% of current AD patients experiencing these symptoms …

Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer's Disease and Osteoporosis

HS Wang, SJ Karnik, TJ Margetts, LI Plotkin… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review This comprehensive review discusses the complex relationship
between Alzheimer's disease (AD) and osteoporosis, two conditions that are prevalent in the …

Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules

N Oumata, K Lu, Y Teng, C Cavé, Y Peng… - European Journal of …, 2022 - Elsevier
The amyloid cascade is the most frequently accepted hypothesis of Alzheimer's Disease
(AD). According to this hypothesis, the formation of plaques precedes the appearance of …

From the mind to the spine: the intersecting world of Alzheimer's and osteoporosis

TJ Margetts, HS Wang, SJ Karnik, LI Plotkin… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review This comprehensive review delves into the intricate interplay
between Alzheimer's disease (AD) and osteoporosis, two prevalent conditions with …

Dietary protection against cognitive impairment, Neuroinflammation and oxidative stress in Alzheimer's disease animal models of lipopolysaccharide-induced …

D Decandia, F Gelfo, E Landolfo, F Balsamo… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a rapidly growing epidemic with a heavy social and economic
burden. Evidence suggests that systemic inflammation, dysregulation of the immune …

Aducanumab in Alzheimer's disease: a critical update

S Ashique, E Sirohi, S Kumar, M Rihan… - Current medicinal …, 2024 - benthamdirect.com
Alzheimer's disease (AD) is a complex neurological disorder that results in cognitive decline.
The incidence rates of AD have been increasing, particularly among individuals 60 years of …

The impact of neurotransmitters on the neurobiology of neurodegenerative diseases

SE Davis, AB Cirincione, AC Jimenez-Torres… - International Journal of …, 2023 - mdpi.com
Neurodegenerative diseases affect millions of people worldwide. Neurodegenerative
diseases result from progressive damage to nerve cells in the brain or peripheral nervous …

Therapeutic potential of targeting mitochondria for Alzheimer's disease treatment

A Atlante, G Amadoro, V Latina, D Valenti - Journal of Clinical Medicine, 2022 - mdpi.com
Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, is
characterized by memory and cognitive impairment and by the accumulation in the brain of …