The importance of radical-induced damage to DNA is apparent from the ever-increasing
number of publications in this area. This review focuses on the damage caused to DNA by …

DNA has for many years been the traditional target for chemotherapeutic intervention1 in
human cancers, especially for those where high proliferation rates of some tumour cell types …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Full details of the development of a simple, nondestructive, and high-throughput method for
establishing DNA binding affinity and sequence selectivity are described. The method is …

The RNA genomes of a number of pathogenic RNA viruses, such as HIV-1, have extensive
folded conformations with imperfect A-form duplexes that are essential for virus function and …

DNA minor groove binders constitute an important class of derivatives in anticancer therapy.
Some of these compounds form noncovalent complexes with DNA (eg, distamycin A …

SMALL molecules that specifically bind with high affinity to any predetermined DNA
sequence in the human genome would be useful tools in molecular biology and potentially …

The solid phase synthesis of sequence specific DNA binding polyamides containing N-
methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Two monomer …

Peptides which bind in the minor groove of DNA as antiparallel side-by-side dimers can be
linked head-to-tail to afford a new class of hairpin oligopeptides with enhanced sequence …

The designed peptides pyridine-2-carboxamide-netropsin (2-PyN) and l-methylimidazole-2-
carboxamide-netropsin (2-ImN) are crescent-shaped synthetic analogs of the natural …