Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases

MI Teixeira, CM Lopes, MH Amaral, PC Costa - European journal of …, 2020 - Elsevier
The central nervous system (CNS) is vulnerable to pathologic processes that lead to the
development of neurodegenerative disorders like Alzheimer's, Parkinson's and Huntington's …

Natural product-based pharmacological studies for neurological disorders

V Puri, N Kanojia, A Sharma, K Huanbutta… - Frontiers in …, 2022 - frontiersin.org
Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …

RGD peptide-mediated liposomal curcumin targeted delivery to breast cancer cells

R Mahmoudi… - Journal of …, 2021 - journals.sagepub.com
In this study, turmeric's active ingredient (Curcumin) was encapsulated into RGD modified
Liposomes (RGD-Lip-Cur) its cytotoxic effect on the breast cancer cell line (MCF-7) was …

Therapeutic application and construction of bilirubin incorporated nanoparticles

Q Yao, R Chen, V Ganapathy, L Kou - Journal of Controlled Release, 2020 - Elsevier
Bilirubin is a yellow-colored metabolite of heme degradation (a bile pigment), once believed
to be toxic, but recently recognized as a powerful endogenous antioxidant of physiologic …

Brain-targeted gene delivery of ZnO quantum dots nanoplatform for the treatment of Parkinson disease

D Lin, M Li, Y Gao, L Yin, Y Guan - Chemical Engineering Journal, 2022 - Elsevier
Accumulation of α-synuclein (SNCA) in the midbrain is considered as a major pathological
characteristic of Parkinson's disease (PD). Inhibiting SNCA expression is an efficient …

Cholesterol‐containing lipid nanodiscs promote an α‐synuclein binding mode that accelerates oligomerization

M Jakubec, E Bariaas, S Furse, ML Govasli… - The FEBS …, 2021 - Wiley Online Library
Dysregulation of the biosynthesis of cholesterol and other lipids has been implicated in
many neurological diseases, including Parkinson's disease. Misfolding of α‐synuclein (α …

The impact of hUC MSC–derived exosome-nanoliposome hybrids on α-synuclein fibrillation and neurotoxicity

F Aliakbari, K Marzookian, S Parsafar, H Hourfar… - Science …, 2024 - science.org
Amyloid aggregation of α-synuclein (αSN) protein amplifies the pathogenesis of
neurodegenerative diseases (NDs) such as Parkinson's disease (PD). Consequently …

Inhibitory effect of plain and functionalized graphene nanoplateles on hen egg white lysozyme fibrillation

S Abbaspour, SH Alijanvand, D Morshedi… - Colloids and Surfaces B …, 2023 - Elsevier
Protein fibrillation is a phenomenon associated with misfolding and the production of highly
ordered nanofibrils, which may cause serious degenerative diseases such as Parkinson's …

Influence of formulation variables on miconazole nitrate–loaded lipid based nanocarrier for topical delivery

PM Al-Maghrabi, ES Khafagy, MM Ghorab… - Colloids and Surfaces B …, 2020 - Elsevier
The purpose of this study was to develop miconazole nitrate (MN) based solid lipid nano-
carrier formulae for topical delivery to enhance its antifungal effectiveness. Miconazole …

Parkinson's disease: a nanotheranostic approach targeting alpha-synuclein aggregation

FLG Zoey, M Palanivel, P Padmanabhan… - Frontiers in Cell and …, 2021 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that is
implicated in aging populations. As numerous developed nations are experiencing …