Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Disrupted protein folding or decreased protein stability can lead to the accumulation of
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …

The spice saffron (Crocus sativus) has anticancer activity in several human tissues, but the
molecular mechanisms underlying its potential therapeutic effects are poorly understood …

Safranal (a monoterpene aldehyde) is the major volatile component of saffron which is
responsible for the saffron unique odor. Several studies have shown the pharmacological …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the
accumulation of α-synuclein (α-Syn) aggregates. However, there are currently no effective …

Introduction Asthma is a chronic and recurring airway disease, which related to mast cell
activation. Many compounds derived from Chinese herbal medicine has promising effects …

Parkinson's disease, the second most prevalent neurodegenerative disorder worldwide, is
characterized by a progressive loss of dopaminergic neurons in substantia nigra pars …

The onset of Alzheimer's disease (AD) is triggered by the aggregation of amyloid β (Aβ)
peptides which leads to the formation of fibrils. Molecules that are able to inhibit fibrillation …

Parkinson's disease (PD) is characterized by the death of dopaminergic neurons. The
common histopathological hallmark in PD patients is the formation of intracellular …

Misfolding and aggregation of α-synuclein (α-syn) play a key role in the pathogenesis of
Parkinson's disease (PD). Herein, the inhibitory effect of ulvan on α-syn fibrillogenesis was …