Building digital twins of the human immune system: toward a roadmap
Digital twins, customized simulation models pioneered in industry, are beginning to be
deployed in medicine and healthcare, with some major successes, for instance in …
deployed in medicine and healthcare, with some major successes, for instance in …
Mechanistic modeling of SARS‐CoV‐2 and other infectious diseases and the effects of therapeutics
AS Perelson, R Ke - Clinical Pharmacology & Therapeutics, 2021 - Wiley Online Library
Modern viral kinetic modeling and its application to therapeutics is a field that attracted the
attention of the medical, pharmaceutical, and modeling communities during the early days of …
attention of the medical, pharmaceutical, and modeling communities during the early days of …
Using digital twins in viral infection
R Laubenbacher, JP Sluka, JA Glazier - Science, 2021 - science.org
When the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
emerged in 2019, researchers rapidly recalibrated epidemiological computer models …
emerged in 2019, researchers rapidly recalibrated epidemiological computer models …
The initial interplay between HIV and mucosal innate immunity
V Caputo, M Libera, S Sisti, B Giuliani… - Frontiers in …, 2023 - frontiersin.org
Human Immunodeficiency Virus (HIV) is still one of the major global health issues, and
despite significant efforts that have been put into studying the pathogenesis of HIV infection …
despite significant efforts that have been put into studying the pathogenesis of HIV infection …
Current and prospective computational approaches and challenges for developing COVID-19 vaccines
Abstract SARS-CoV-2, which causes COVID-19, was first identified in humans in late 2019
and is a coronavirus which is zoonotic in origin. As it spread around the world there has …
and is a coronavirus which is zoonotic in origin. As it spread around the world there has …
Intracellular life cycle kinetics of SARS-CoV-2 predicted using mathematical modelling
D Grebennikov, E Kholodareva, I Sazonov… - Viruses, 2021 - mdpi.com
SARS-CoV-2 infection represents a global threat to human health. Various approaches were
employed to reveal the pathogenetic mechanisms of COVID-19. Mathematical and …
employed to reveal the pathogenetic mechanisms of COVID-19. Mathematical and …
Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection
A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary
dramatically across individuals. Because spatial-temporal dynamics of viral spread and …
dramatically across individuals. Because spatial-temporal dynamics of viral spread and …
[HTML][HTML] Multiscale model of antiviral timing, potency, and heterogeneity effects on an epithelial tissue patch infected by SARS-CoV-2
We extend our established agent-based multiscale computational model of infection of lung
tissue by SARS-CoV-2 to include pharmacokinetic and pharmacodynamic models of …
tissue by SARS-CoV-2 to include pharmacokinetic and pharmacodynamic models of …
Biophysical models of early mammalian embryogenesis
Embryo development is a critical and fascinating stage in the life cycle of many organisms.
Despite decades of research, the earliest stages of mammalian embryogenesis are still …
Despite decades of research, the earliest stages of mammalian embryogenesis are still …
Spatial information allows inference of the prevalence of direct cell–to–cell viral infection
T Williams, JM McCaw, JM Osborne - PLOS Computational …, 2024 - journals.plos.org
The role of direct cell–to–cell spread in viral infections—where virions spread between host
and susceptible cells without needing to be secreted into the extracellular environment—has …
and susceptible cells without needing to be secreted into the extracellular environment—has …