The importance of eukaryotic DNA methylation [5-methylcytosine (5mC)] in transcriptional
regulation and development was first suggested almost 40 years ago. However, the …

Genetic information is encoded by the four bases adenine (A), guanine (G), cytosine (C),
and thymine (T). Base pairing through hydrogen bonding between the cognate pairs AT and …

Ten-eleven translocation 1 (TET1) protein has the potential to accelerate the oxygenation of
5-methylcytosine to 5-hydroxymethylcytosine (5hmC); then the− CH2OH of 5hmC can further …

Very preterm (VPT) infants need long-lasting hospitalization in the Neonatal Intensive Care
Unit (NICU) during which they are daily exposed to pain-related stress. Alterations of DNA …

Methylcytosine (5 mC) is considered to play a key regulating role in gene transcription and
can be oxidized by ten–eleven translocation (TET) dioxygenases to 5 …

Prenatal exposure to neurotoxicants such as lead (Pb) may cause stable changes in the
DNA methylation (5mC) profile of the fetal genome. However, few studies have examined its …

Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and
differentiation driving extracellular matrix modulation necessary to form a stabilizing scar …

Genomic imprinting is an epigenetic process that distinguishes parental alleles, resulting in
parent‐specific expression of a gene or cluster of genes. Imprints are acquired during …

Abstract Background Differences in 5-hydroxymethylcytosine, 5hmC, distributions may
complicate previous observations of abnormal cytosine methylation statuses that are used …

Transposable elements (TEs) are the major sources of lineage-specific genomic innovation
and comprise nearly half of the human genome, but most of their functions remain unclear …