Pathogenetic features and current management of glioblastoma
Simple Summary Glioblastoma (GBM) is the most common form of primary malignant brain
tumor with a devastatingly poor prognosis. Tumor heterogeneity (cellular, molecular and …
tumor with a devastatingly poor prognosis. Tumor heterogeneity (cellular, molecular and …
Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence
Glioblastoma (GBM) is the most common primary brain tumor and is highly aggressive with a
median survival of 15 months. We have previously shown that residual cells of GBM form …
median survival of 15 months. We have previously shown that residual cells of GBM form …
Substrate stiffness regulates the recurrent glioblastoma cell morphology and aggressiveness
Recurrent glioblastoma is highly aggressive with currently no specific treatment regime.
Therefore, to identify novel therapeutic targets for recurrent GBM, we used a cellular model …
Therefore, to identify novel therapeutic targets for recurrent GBM, we used a cellular model …
Inhibition of SETMAR–H3K36me2–NHEJ repair axis in residual disease cells prevents glioblastoma recurrence
Background Residual disease of glioblastoma (GBM) causes recurrence. However,
targeting residual cells has failed, due to their inaccessibility and our lack of understanding …
targeting residual cells has failed, due to their inaccessibility and our lack of understanding …
Nuclear localization of p65 reverses therapy-induced senescence
Senescence is the arrest of cell proliferation and is a tumor suppressor phenomenon. In a
previous study, we have shown that therapy-induced senescence of glioblastoma multiforme …
previous study, we have shown that therapy-induced senescence of glioblastoma multiforme …
TRIM56 reduces radiosensitization of human glioblastoma by regulating FOXM1-Mediated DNA repair
Y Dong, Y Xiong, D Zhou, M Yao, X Wang, W Bi… - Molecular …, 2022 - Springer
Recurrent glioblastoma is characterized by resistance to radiotherapy or chemotherapy. In
this study, we investigated the role of TRIM56 in radiosensitization and its potential …
this study, we investigated the role of TRIM56 in radiosensitization and its potential …
[HTML][HTML] Birth of a solid organ cancer—the cell fusion hypothesis presented with pancreatic cancer as a model: a narrative review
SG Barreto, N Gardi, S Dutt - Chinese Clinical Oncology, 2021 - cco.amegroups.org
Objective: This hypothesis-driven narrative review aims to explore the evidence for the
fundamental process of cell fusion between normal, but different, cell types in the genesis of …
fundamental process of cell fusion between normal, but different, cell types in the genesis of …
DUSP6 regulates radiosensitivity in glioblastoma by modulating the recruitment of phosphorylated DNAPKcs at DNA double-strand breaks
J Nair, S Basha Syed, T Mahaddalkar… - Journal of Cell …, 2021 - journals.biologists.com
Glioblastoma (GBM) has poor median survival due to its resistance to chemoradiotherapy,
which results in tumor recurrence. Recurrent GBMs currently lack effective treatments …
which results in tumor recurrence. Recurrent GBMs currently lack effective treatments …
Inhibition of PERK mediated UPR acts as a switch for reversal of residual senescence and as senolytic therapy in glioblastoma
Background Glioblastoma due to recurrence is clinically challenging with 10-15months
overall survival. Previously we showed therapy induced senescence (TIS) in glioblastoma …
overall survival. Previously we showed therapy induced senescence (TIS) in glioblastoma …
14-3-3ζ negatively regulates mitochondrial biogenesis in GBM residual cells
Glioblastoma (GBM) is the most lethal primary brain tumour with a median survival of only 15
months. We have previously demonstrated the generation of an in vitro therapy resistance …
months. We have previously demonstrated the generation of an in vitro therapy resistance …