Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease

DM Tebit, EJ Arts - The Lancet infectious diseases, 2011 - thelancet.com
Since the isolation of HIV, multiple transmissions are thought to have occurred between man
and other old-world primates. Assessment of samples from apes and human beings with …

Analysis of a local HIV-1 epidemic in portugal highlights established transmission of non-B and non-G subtypes

A Carvalho, P Costa, V Triunfante… - Journal of clinical …, 2015 - Am Soc Microbiol
The existing data support Portugal as the western European country with the highest HIV-1
subtype diversity. However, detailed phylogenetic studies of Portuguese HIV-1 epidemics …

Origin and epidemiological history of HIV-1 CRF14_BG

I Bartolo, AB Abecasis, P Borrego, H Barroso… - PLoS …, 2011 - journals.plos.org
Background CRF14_BG isolates, originally found in Spain, are characterized by CXCR4
tropism and rapid disease progression. This study aimed to identify the origin of CRF14_BG …

Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodomain contributes to reduce viral burden in HIV-1 infected patients

R Marcelino, F Gramacho, F Martin, P Brogueira… - Scientific Reports, 2021 - nature.com
The ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs)
and is being explored in new strategies for antibody-based HIV vaccines. Previous studies …

Molecular epidemiology of HIV type 1 CRF02_AG in Cameroon and African patients living in Italy

NMC Véras, MM Santoro, RR Gray… - AIDS research and …, 2011 - liebertpub.com
Abstract HIV-1 CRF02_AG accounts for> 50% of infected individuals in Cameroon.
CRF02_AG prevalence has been increasing both in Africa and Europe, particularly in Italy …

Near full-length genetic analysis of HIV sequences derived from Cyprus: evidence of a highly polyphyletic and evolving infection

I Kousiappa, DAMC Van De Vijver… - AIDS research and …, 2009 - liebertpub.com
The molecular epidemiology of HIV-1 infection was previously studied in Cyprus but the
degree of HIV-1 diversity has remained indefinable. The main objective of the present study …

Meta-Analysis To Test the Association of HIV-1 nef Amino Acid Differences and Deletions with Disease Progression

R Pushker, JM Jacqué, DC Shields - Journal of virology, 2010 - Am Soc Microbiol
Previous relatively small studies have associated particular amino acid replacements and
deletions in the HIV-1 nef gene with differences in the rate of HIV disease progression. We …

Genetic characterization of complex inter‐recombinant HIV‐1 strains circulating in Spain and reliability of distinct rapid subtyping tools

A Holguín, E Lospitao, M Lopez… - Journal of medical …, 2008 - Wiley Online Library
Genetic recombination and high rate of mutation increase HIV‐1 diversity, allowing viruses
to escape more easily from the host immune response or antiretroviral drugs. The …

Novel multiregion hybridization assay for the identification of the most prevalent genetic forms of the human immunodeficiency virus type 1 circulating in Portugal

FB Freitas, A Esteves, J Piedade… - AIDS research and …, 2013 - liebertpub.com
The most efficient method for HIV-1 genetic characterization involves full-genome
sequencing, but the associated costs, technical features, and low throughput preclude it from …

Potential Impact of Viral Load and Genetic Makeup of HIV Type 1 on Mother-to-Child Transmission: Characterization of env-C2V3C3 and nef Sequences

E Pádua, R Parreira, R Tendeiro, B Nunes… - AIDS research and …, 2009 - liebertpub.com
Abstract HIV-1 mother-to-child transmission (MTCT) was evaluated in terms of the molecular
characterization of the env and nef genomic regions and quantification of maternal RNA viral …