Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The
seven P2X receptor subtypes are implicated in physiological processes that include …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …

ATP acts as a humoral mediator to control cell function extracellularly. The receptors that
mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the …

There are seven P2X receptor cDNAs currently known. Six homomeric (P2X1, P2X2, P2X3,
P2X4, P2X5, P2X7) and three heteromeric (P2X2/P2X3, P2X4/P2X6, P2X1/P2X5) P2X …

P2X receptors are cation channels gated by extracellular ATP. The seven known P2X
isoforms possess no sequence homology with other proteins. Here we studied the …

There are few antagonists selective for subtypes of the several P2X receptors, but these are
needed to identify the receptors expressed on native cells and tissues. In particular, P2X4 …