The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …

Objective The purpose of this article is to review the association of the obesity pandemic with
appearance of cancers in young adults under age 50 and to define potential mechanisms by …

Background Clinical management of women carrying a germline pathogenic variant (PV) in
the BRCA1/2 genes demands for accurate age-dependent estimators of breast cancer (BC) …

Abstract Aim and Background Environmental exposures are known to play a role in the
development of cancer, including breast cancer. There are known associations of breast …

Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused
by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most …

Context Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant
hereditary disease caused by the loss of function of the MEN1 gene, a tumor-suppressor …

Objective Multiple endocrine neoplasia 2B (MEN2B) is characterised by early‐onset
medullary thyroid carcinoma (MTC), pheochromocytoma and several nonendocrine …

Background Lynch syndrome (LS) is an autosomal‐dominant, hereditary cancer
predisposition syndrome caused by pathogenic variants (PVs) in one of the mismatch‐repair …

Objective To study the anticipation phenomenon among hereditary breast cancer patients,
by evaluating trends in age at diagnosis and phenotype of breast cancer across two …

Children's literacy about the genetics of late-onset hereditary breast/ovarian cancer (HBOC)
often develops through conversations with parents about BRCA gene testing and adults' …