Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause of
cancer death among women worldwide. Globally, BC is the second most frequent cancer …

Breast cancer incidence is actually the highest one among all cancers. Overall breast cancer
management is associated with challenges considering risk assessment and predictive …

Designing molecules for drugs has been a hot topic for many decades. However, it is hard
and expensive to find a new molecule. Thus, the cost of the final drug is also increased …

Aromatase inhibition is considered a legitimate approach for the treatment of ER-positive
(ER+) breast cancer as it accounts for more than 70% of breast cancer cases. Aromatase …

The promising antitumor effects of progesterone derivatives have been identified in many
studies. However, the specific mechanism of action of this class of compounds has not been …

Discovery of SERDs has changed the direction of anticancer research, as more than 70% of
breast cancer cases are estrogen receptor positive (ER+). Therapies such as selective …

Background: Cancer is the second leading cause of death worldwide. Many anticancer
drugs are commercially available, but lack of selectivity, target specificity, cytotoxicity, and …

VEGFR-2 is a tyrosine kinase receptor for VEGFs that play a central role in tumor
angiogenesis. The inhibition of the tyrosine kinase domain of VEGFR-2 has become an …

For many years, luteinizing hormone-releasing hormone or gonadotropin-releasing
hormone (GnRH) analogs have been used to treat androgen or estrogen-dependent tumors …

Coumarin is a bicyclic oxygen bearing heterocyclic scaffold formed by fusion of benzene
with the pyrone ring. Because of its unique physicochemical characteristics and the ease …