Effects of dietary components on mast cells: possible use as nutraceuticals for allergies?

S Kaag, A Lorentz - Cells, 2023 - mdpi.com
Allergic diseases affect an estimated 30 percent of the world's population. Mast cells (MC)
are the key effector cells of allergic reactions by releasing pro-inflammatory mediators such …

Nutritional activities of luteolin in obesity and associated metabolic diseases: an eye on adipose tissues

Z Zhang, J Wang, Y Lin, J Chen, J Liu… - Critical Reviews in Food …, 2024 - Taylor & Francis
Obesity is characterized by excessive body fat accumulation and is a high-risk factor for
metabolic comorbidities, including type 2 diabetes, nonalcoholic fatty liver disease, and …

Anti-inflammatory chemical constituents of Flos Chrysanthemi Indici determined by UPLC-MS/MS integrated with network pharmacology

D Tian, Y Yang, M Yu, ZZ Han, M Wei, HW Zhang… - Food & function, 2020 - pubs.rsc.org
Flos Chrysanthemi Indici (FCI), the flower of Chrysanthemum indicum L., is a common
functional food and a well-known traditional Chinese medicine (TCM) for the treatment of …

Reparative effects of ethanol-induced intestinal barrier injury by flavonoid luteolin via MAPK/NF-κB/MLCK and Nrf2 signaling pathways

J Yuan, S Che, L Zhang, Z Ruan - Journal of Agricultural and Food …, 2021 - ACS Publications
Luteolin, a dietary flavonoid, has gained increasing interest as an intestinal protectant. This
study aimed to evaluate the reparative effect of luteolin against ethanol-induced intestinal …

Cytokines stimulated by IL-33 in human skin mast cells: Involvement of NF-κB and p38 at distinct levels and potent co-operation with FcεRI and MRGPRX2

K Franke, Z Wang, T Zuberbier, M Babina - International Journal of …, 2021 - mdpi.com
The IL-1 family cytokine IL-33 activates and re-shapes mast cells (MCs), but whether and by
what mechanisms it elicits cytokines in MCs from human skin remains poorly understood …

Luteolin suppresses microglia neuroinflammatory responses and relieves inflammation-induced cognitive impairments

W Zhou, M Hu, J Hu, Z Du, Q Su, Z Xiang - Neurotoxicity Research, 2021 - Springer
Microglia-mediated neuroinflammation in response to injurious self and non-self-stimuli
exerts detrimental effects on neurons, which may lead to cognitive impairment. Luteolin, a …

A network pharmacology approach to explore the mechanism of HuangZhi YiShen capsule for treatment of diabetic kidney disease

XF Zhou, WE Zhou, WJ Liu, MJ Luo, XQ Wu… - Journal of translational …, 2021 - degruyter.com
Abstract Background and Objective HuangZhi YiShen Capsule (HZYS) is a Chinese patent
herbal drug that protects kidney function in diabetic kidney disease (DKD) patients …

Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia

Q Li, P Liu, C Wu, L Bai, Z Zhang, Z Bao, M Zou… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Shi Wei Ru Xiang powder (SWR) is a traditional
Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In …

Luteolin Is More Potent than Cromolyn in Their Ability to Inhibit Mediator Release from Cultured Human Mast Cells

I Tsilioni, T Theoharides - International Archives of Allergy and …, 2024 - karger.com
Introduction: Mast cells are known for their involvement in allergic reactions but also in
inflammatory reactions via secretion of numerous pro-inflammatory chemokines, cytokines …

Strategies targeting IL-33/ST2 axis in the treatment of allergic diseases

W Li, M Liu, M Chu - Biochemical Pharmacology, 2023 - Elsevier
Abstract Interleukin-33 (IL-33) and its receptor Serum Stimulation-2 (ST2, also called Il1rl1)
are members of the IL-1 superfamily that plays a crucial role in allergic diseases. The …