Genetic and epigenetic regulation of gene expression in fetal and adult human livers

MJ Bonder, S Kasela, M Kals, R Tamm, K Lokk… - BMC genomics, 2014 - Springer
Background The liver plays a central role in the maintenance of homeostasis and health in
general. However, there is substantial inter-individual variation in hepatic gene expression …

Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow

BM Soares, TMT Araújo, JAB Ramos… - Anticancer …, 2015 - ar.iiarjournals.org
Tartrazine is a food additive that belongs to a class of artificial dyes and contains an azo
group. Studies about its genotoxic, cytotoxic and mutagenic effects are controversial and, in …

Glutathione S-transferases class Pi and Mi and their significance in oncology.

Z Marchewka, A Piwowar, S Ruzik… - Postepy higieny i …, 2017 - europepmc.org
In this article the current data, which shows that glutathione S-transferases (GST) class Pi
and Mi are interesting and promising biomarkers in acute and chronic inflammatory …

Computational insight of antioxidant and doxorubicin combination for effective cancer therapy

J Nayak, SV P, SK Sahoo, M Kumar… - Journal of …, 2024 - Taylor & Francis
Doxorubicin (DOX) is the most effective antineoplastic agent, destroys cancer cells by
interrupting cellular function. However, the serious side effects on the heart limits its utility …

Association Between Polymorphisms of Glutathione S-Transferase Genes (GSTM1, GSTP1 and GSTT1) and Breast Cancer Risk in a Sample Iranian Population

M Hashemi, E Eskandari-Nasab, A Fazaeli… - Biomarkers in …, 2012 - Taylor & Francis
Aim: Genetic and environmental factors are risk factors for breast cancer. Our aim was to
investigate the associations between genetic polymorphism of GST genes (GSTM1, GSTT1 …

Is the combinational administration of doxorubicin and glutathione a reasonable proposal?

B Shen, C Chen, Y Xu, J Shen, H Guo, H Li… - Acta Pharmacologica …, 2019 - nature.com
The combinational administration of antioxidants and chemotherapeutic agents during
conventional cancer treatment is among one of the most controversial areas in oncology …

Cytogenetic endpoints and Xenobiotic gene polymorphism in lymphocytes of hospital workers chronically exposed to ionizing radiation in Cardiology, Radiology and …

B Vellingiri, S Shanmugam, MD Subramaniam… - Ecotoxicology and …, 2014 - Elsevier
Ionizing radiation (IR) is known as a classical mutagen capable of inducing various kinds of
stable and unstable chromosomal aberrations (CA) including the possibility of increasing the …

CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case–control study

S Akhtar, I Mahjabeen, Z Akram, MA Kayani - Familial cancer, 2016 - Springer
In first part of this study, a systematic review was designed to explore the involvement of
CYP1A1 and GSTP1 genes in breast cancerogenesis. Based on systematic review, we …

Synthesis and biological activity of 6-selenocaffeine: potential modulator of chemotherapeutic drugs in breast cancer cells

IL Martins, JP Miranda, NG Oliveira, AS Fernandes… - Molecules, 2013 - mdpi.com
We report the development of a new microwave-based synthetic methodology mediated by
Woollins' reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A …

Perceived stress levels, chemotherapy, radiation treatment and tumor characteristics are associated with a persistent increased frequency of somatic chromosomal …

N Aboalela, D Lyon, RK Elswick Jr, DL Kelly… - PLoS …, 2015 - journals.plos.org
While advances in therapeutic approaches have resulted in improved survival rates for
women diagnosed with breast cancer, subsets of these survivors develop persistent …