Taurine is a natural amino acid present as free form in many mammalian tissues and in
particular in skeletal muscle. Taurine exerts many physiological functions, including …

Voltage-gated sodium channels open (activate) when the membrane is depolarized and
close on repolarization (deactivate) but also on continuing depolarization by a process …

Local anesthetic drugs interfere with excitation and conduction by action potentials in the
nervous system and in the heart by blockade of the voltage-gated Na channel. Drug affinity …

Sodium channels play an important role in the neuronal network by transmitting electrical
impulses rapidly throughout cells and cell networks, thereby coordinating higher processes …

(S)-as well as (R)-mexiletine [1-(2, 6-dimethylphenoxy)-2-propanamine], a chiral orally
effective antiarrhythmic agent, was prepared by deracemization starting from the …

Modeling cardiac disorders with human induced pluripotent stem cell (hiPSC)-derived
cardiomyocytes is a new paradigm for preclinical testing of candidate therapeutics …

Cyclometalated iridium complexes are found to be versatile catalysts for the direct reductive
amination (DRA) of carbonyls to give primary amines under transfer‐hydrogenation …

Lewis acid catalyzed quaternary ammonium salt mediated highly regioselective ring-
opening of chiral activated aziridines and azetidines with alcohols to nonracemic β-and γ …

Taurine is abundantly present in skeletal muscle. We give evidence that this amino acid
exerts both short-term and long-term actions in the control of ion channel function and …

More than 400 genes are known that encode ion channel subunits. In addition, alternative
splicing and heteromeric assembly of different subunits increase tremendously the variety of …