5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology

ME Maffei - International journal of molecular sciences, 2020 - mdpi.com
L-5-hydroxytryptophan (5-HTP) is both a drug and a natural component of some dietary
supplements. 5-HTP is produced from tryptophan by tryptophan hydroxylase (TPH), which is …

Hypothalamic dopamine and serotonin in the regulation of food intake

MM Meguid, SO Fetissov, M Varma, T Sato, L Zhang… - Nutrition, 2000 - Elsevier
Because daily food intake is the product of the size of a meal and the frequency of meals
ingested, the characteristic of meal size to meal number during a 24-h light–dark cycle …

Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan

C Cangiano, F Ceci, A Cascino, M Del Ben… - The American journal of …, 1992 - Elsevier
Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP)
without dietary prescriptions causes anorexia, decreased food intake, and weight loss in …

Pharmacological targeting of the serotonergic system for the treatment of obesity

AS Garfield, LK Heisler - The Journal of Physiology, 2009 - Wiley Online Library
The attenuation of food intake as induced by an increase in serotonergic (5‐
hydroxytryptamine, 5‐HT) efficacy has been a target of antiobesity pharmacotherapies …

Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes

DD Lam, LK Heisler - Expert reviews in molecular medicine, 2007 - cambridge.org
The neurotransmitter serotonin is an important regulator of energy balance. In the brain,
serotonergic fibres from midbrain raphe nuclei project to key feeding centres, where …

[图书][B] Handbook of Obesity-Volume 2: Clinical Applications

G Bray, C Bouchard - 2014 - books.google.com
Several major developments have occurred since the last edition of Handbook of Obesity:
Clinical Applications, including new clinical trials, discoveries related to drug use, and …

Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients

C Cangiano, A Laviano, M Del Ben, I Preziosa… - International journal of …, 1998 - nature.com
OBJECTIVE: In obese patients, brain serotonergic stimulation via orally administered 5-
hydroxy-tryptophan (5-HTP), the precursor of serotonin, causes decreased carbohydrate …

Risk associated with the use of selected ingredients in food supplements

K Jędrejko, J Lazur, B Muszyńska - Chemistry & Biodiversity, 2021 - Wiley Online Library
This review focuses on four new product categories of food supplements: pre‐workout, fat
burner/thermogenic, brain/cognitive booster, and hormone/testosterone booster. Many food …

Pharmaceutical combinations for treating obesity and food craving

RB Rothman - US Patent 6,207,699, 2001 - Google Patents
Numerous studies have documented that medications which increase brain serotonin (5-HT)
are effective anorectic agents which help obese patients lose weight and which also …

The presence of unauthorized ingredients in dietary supplements: an analysis of the risk warning data in Korea

D Shin, J Kwon, HS Kang, J Suh, E Lee - Journal of Food Composition and …, 2022 - Elsevier
Abstract The Ministry of Food and Drug Safety (MFDS) has identified that numerous dietary
supplements contain unapproved (hidden, undeclared, and unauthorized) ingredients that …