Cholesterol plays an important role in cancer development. Both clinical and experimental
studies have found that hypercholesterolemia and a high-fat high-cholesterol diet can affect …

The female sex hormone estrogen has been ascribed potent neuroprotective properties. It
signals by binding and activating estrogen receptors that, depending on receptor subtype …

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

The interplay between cellular stress and immune response can be variable and sometimes
contradictory. The mechanisms by which stress-activated pathways regulate the …

To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that
promotes ER+ breast tumor growth. We report that the cholesterol metabolite 27 …

Several studies show that a significantly stronger association is obvious between increased
body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are …

Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

Simple Summary Metabolic reprogramming is gaining attentions as a hallmark of cancers.
However, lipid metabolism has been difficult to analyze due to technical problems. In recent …

Cholesterol is a risk factor for breast cancer although the mechanisms by which this occurs
are not well understood. One hypothesis is that dyslipidemia results in increased cholesterol …

Metabolic syndrome is a type of multifactorial metabolic disease with the presence of at least
three factors: obesity, diabetes mellitus, low high-density lipoprotein, hypertriglyceridemia …