Aminoacyl-tRNA synthetases are central enzymes in protein translation, providing the
charged tRNAs needed for appropriate construction of peptide chains. These enzymes have …

Parasitic diseases result in considerable human morbidity and mortality. The continuous
emergence and spread of new drug-resistant parasite strains is an obstacle to controlling …

Summary The Chinese herb Dichroa febrifuga has traditionally treated malaria-associated
fever. Its active component febrifugine (FF) and derivatives such as halofuginone (HF) are …

Developing anti-parasitic lead compounds that act on key vulnerabilities are necessary for
new anti-infectives. Malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis and coccidiosis …

The Rossmann-like fold is the most prevalent and diversified doubly-wound superfold of
ancient evolutionary origin. Rossmann-like domains are present in a variety of metabolic …

Highlights•Malaria remains a killer disease and drug resistance poses a growing
problem.•Aminoacyl tRNA synthetases (aaRSs) are essential housekeeping …

Malaria parasites inevitably develop drug resistance to anti-malarials over time. Hence the
immediacy for discovering new chemical scaffolds to include in combination malaria drug …

The Plasmodium falciparum protein translation enzymes aminoacyl-tRNA synthetases
(aaRSs) are an emergent family of drug targets. The aaRS ensemble catalyses transfer of …

Background Treatment of parasitic diseases has been challenging due to evolution of drug
resistant parasites, and thus there is need to identify new class of drugs and drug targets …

The malaria parasite Plasmodium falciparum relies on efficient protein translation. An
essential component of translation is the tryptophanyl-tRNA synthetase (TrpRS) that charges …