Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease

H Alfakry, E Malle, CN Koyani, PJ Pussinen… - Innate …, 2016 - journals.sagepub.com
Cardiovascular diseases are chronic inflammatory diseases that affect a large segment of
society. Coronary heart disease (CHD), the most common cardiovascular disease …

Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NFκB and Nrf-2/HO-1 signaling crosstalk

S Saber, RM Khalil, WS Abdo, D Nassif… - Toxicology and applied …, 2019 - Elsevier
Alteration in the expression pattern of Nrf-2 and NFκB has been reported in ulcerative colitis
(UC) in which functional crosstalk between these two critical pathways has been suggested …

[HTML][HTML] Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

A Chor, MA Skeff, C Takiya, R Gonçalves, M Dias… - Oncotarget, 2021 - ncbi.nlm.nih.gov
Clinical guidelines for oral mucositis (OM) still consist in palliative care. Herein, we
summarize cellular and molecular mechanisms of OM ulceration in response to chemical …

Telmisartan ameliorates dextran sodium sulfate-induced colitis in rats by modulating NF-κB signalling in the context of PPARγ agonistic activity

S Saber, M Basuony, AS Eldin - Archives of biochemistry and biophysics, 2019 - Elsevier
Variations in Nrf-2 and NF-κB expression profiles have been reported in ulcerative colitis
(UC), in which an interplay between these two critical pathways has been identified. The …

Causal associations of MICB, CTSA, and MMP9 proteins with oral cancer: Mendelian randomization study

B Dong, J Hua, S Ma, L Wang, H Xiao, X Qiao… - Scientific Reports, 2024 - nature.com
Oral cancer (ORCA) is the most prevalent histological subtype of oral malignancies in which
immune modulation is relevant. The goal of this work was to employ Mendelian …

Azilsartan Attenuates 3-Nitropropinoic Acid-Induced Neurotoxicity in Rats: The Role of IĸB/NF-ĸB and KEAP1/Nrf2 Signaling Pathways

HA Hamouda, RH Sayed, NI Eid, BM El-Sayeh - Neurochemical Research, 2024 - Springer
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder
characterized by motor, psychiatric and cognitive symptoms. Injection of 3-nitropropionic …

Azilsartan reduced TNF-α and IL-1β levels, increased IL-10 levels and upregulated VEGF, FGF, KGF, and TGF-α in an oral mucositis model

AA de Araújo, H Varela, CACX de Medeiros… - PloS one, 2015 - journals.plos.org
Oral mucositis (OM) is a common complication of treatments for head and neck cancer,
particularly radiotherapy with or without chemotherapy. OM is characterised by oral …

Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats

JTM Alexandre, LHT Sousa, MRP Lisboa… - Clinical oral …, 2018 - Springer
Objective The aim of this work was to evaluate the anti-inflammatory and antiresorptive
effects of Calendula officinalis (CLO) on alveolar bone loss (ABL) in rats. Material and …

Azilsartan suppressed LPS-induced inflammation in U937 macrophages through suppressing oxidative stress and inhibiting the TLR2/MyD88 signal pathway

Q Dong, Y Li, J Chen, N Wang - ACS omega, 2020 - ACS Publications
Background and purpose: Lipopolysaccharide (LPS) is an important factor that induce
severe inflammation, resulting in multiple types of diseases. It is reported that LPS-induced …

Therapeutic effect of bone marrow mesenchymal stem cells pretreated with acetylsalicylic acid on experimental periodontitis in rats

Y Zhang, Y Xiong, X Chen, C Chen, Z Zhu… - International …, 2018 - Elsevier
Periodontitis is a local inflammatory environment with dysregulation of host responses,
which results in destruction of periodontal tissues. Mesenchymal stem cells (MSCs) have …