The biological effects of environmental metal contamination are important issues in an
industrialized, resource-dependent world. Different metals have different roles in biology …

Highlights•Metal ions serve as cofactors, essential to protein function.•Insects sense,
regulate and mobilize metal ions with chemical specificity.•Metal ions are transferred to the …

The platinum (Pt)-containing antitumor drugs including cisplatin (cis-
diamminedichloroplatinum II, cDDP), carboplatin, and oxaliplatin, have been the mainstay of …

Highlights•Novel protein Gawky is required for the metal-induced nuclear translocation of
MTF-1.•Scox is critical for mitochondrial morphogenesis and function in ensheathing …

Insect epidermal cells secrete a cuticle that serves as an exoskeleton providing mechanical
rigidity to each individual, but also insulation, camouflage or communication within their …

Growth is an important toxicity end-point in ecotoxicology but is rarely used in soil
ecotoxicological studies. Here, we assessed the growth change of Oppia nitens when …

Copper ions play a crucial role in various cellular biological processes. However, these
copper ions can also lead to toxicity when their concentration is not controlled by a …

Accumulating evidence suggests that superoxide dismutase (SOD) is the first line of
antioxidant defense in organisms and plays an important role in scavenging reactive oxygen …

Drosophila brain has emerged as a powerful model system for the investigation of genes
being related to neurological pathologies. To map the proteomic landscape of fly brain, in a …

The following thesis investigates the impact of biological sex and genetic background on the
response to copper and nickel toxicity in Drosophila melanogaster. Sex differences are …